Al Al-Bayt University, Mafraq, Jordan.
Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
Cell Biol Int. 2024 Nov;48(11):1601-1611. doi: 10.1002/cbin.12231. Epub 2024 Aug 20.
This study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified as a crucial factor in the development and progression of breast cancer. The essay explains the complex molecular mechanisms through which mTOR inhibitors, such as rapamycin and its analogs, exert their anticancer effects. These inhibitors can stop cell growth, proliferation, and survival in breast cancer cells by blocking critical signaling pathways within the mTOR pathway. Furthermore, the essay discusses the implications of using mTOR inhibitors as a comprehensive therapeutic strategy. It emphasizes the potential benefits of combining mTOR inhibitors with other treatment approaches to enhance the effectiveness of breast cancer treatment. The evolving landscape of breast cancer research underscores the significance of mTOR as a therapeutic target and highlights ongoing efforts to improve and optimize mTOR inhibitors for clinical use. In conclusion, the essay asserts that inhibitors of the mTOR signaling pathway offer a promising approach in the fight against breast cancer. These inhibitors provide a focused and effective intervention targeting specific dysregulations within the mTOR pathway. As research advances, the integration of mTOR inhibitors into customized combination therapies holds excellent potential for shaping a more effective and personalized approach to breast cancer treatment, ultimately leading to improved outcomes for individuals affected by this complex and diverse disease.
本研究探讨了针对哺乳动物雷帕霉素靶蛋白(mTOR)信号通路的抑制剂在乳腺癌研究和治疗中的关键作用。mTOR 通路是细胞过程的中央调节剂,已被确定为乳腺癌发生和发展的关键因素。本文解释了 mTOR 抑制剂(如雷帕霉素及其类似物)发挥抗癌作用的复杂分子机制。这些抑制剂通过阻断 mTOR 通路内的关键信号通路,阻止乳腺癌细胞的生长、增殖和存活。此外,本文还讨论了将 mTOR 抑制剂用作综合治疗策略的意义。它强调了将 mTOR 抑制剂与其他治疗方法结合使用以提高乳腺癌治疗效果的潜力。乳腺癌研究的不断发展突显了 mTOR 作为治疗靶点的重要性,并强调了正在努力改进和优化 mTOR 抑制剂用于临床应用。总之,本文断言,mTOR 信号通路的抑制剂为抗击乳腺癌提供了一种有前途的方法。这些抑制剂针对 mTOR 通路内的特定失调提供了一种集中而有效的干预措施。随着研究的进展,将 mTOR 抑制剂纳入定制的联合治疗中具有巨大的潜力,可以为乳腺癌治疗制定更有效和个性化的方法,最终为受这种复杂和多样化疾病影响的个体带来更好的结果。