Islam A N M Shamsul, Farhana Nasreen, Choudhury Rafaat, Jahan Naznin Akter, Uddin Mohammad Jamal, Refat Md Nazmul Hassan, Nasreen Fatima, Khanam Fahmida
Department of Public Health and Hospital Administration, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.
Department of Microbiology and Mycology, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.
Access Microbiol. 2024 Aug 20;6(8). doi: 10.1099/acmi.0.000727.v3. eCollection 2024.
This study aimed to determine patterns of respiratory, blood-borne and uropathogenic microbial pathogens among SARS-CoV-2-infected patients in a COVID-19-(coronavirus disease 2019) dedicated tertiary care hospital in Dhaka, Bangladesh. This was a cross-sectional study. In a COVID-19-dedicated tertiary care hospital in Dhaka, Bangladesh, conducted from March to June 2021. Hospitalized individuals with COVID-19 infection regardless of age or sex. The percentage of co-infected COVID-19 patients and the characterization of the micro-organisms responsible for co-infection served as the primary outcome measures. Finding any associations between co-infection and age, co-infection and sex and co-infection and comorbidity was the secondary outcome variable. Not applicable. Out of 79 patients, 61 % were male, and the mean age was 49.53 years. Co-infection was seen in 7.7 % of patients, out of which 5.1 % of isolates were from urine samples, followed by 2.6 % from blood. Bacteria isolated from urine were (2.6 %), coagulase-negative (CONS) (1.3 %) and spp. (1.3 %). spp. was the only organism isolated from blood sample. Mixed growth was found in nasopharyngeal and throat swabs, with the predominant species being Staphylococcus aureus and Streptococcus spp. At the time of data collection, 55.7 % of patients had been given antimicrobials, and 30.4 % of patients had been given a single antimicrobial. HBsAg was positive in 1.3 % of patients and none were anti-hepatitis C or dengue NS1Ag positive. Microbial infection has been seen to be associated with SARS-CoV-2 infections and is of great value in prescribing antimicrobials and reducing fatal outcomes of hospitalized patients.
本研究旨在确定在孟加拉国达卡一家专门治疗新冠肺炎（2019冠状病毒病）的三级护理医院中，感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的患者的呼吸道、血源和尿路致病性微生物病原体模式。这是一项横断面研究。于2021年3月至6月在孟加拉国达卡一家专门治疗新冠肺炎的三级护理医院开展。纳入了感染新冠肺炎的住院患者，不限年龄和性别。新冠病毒合并感染患者的百分比以及导致合并感染的微生物特征作为主要结局指标。发现合并感染与年龄、合并感染与性别以及合并感染与合并症之间的任何关联是次要结局变量。不适用。在79名患者中，61%为男性，平均年龄为49.53岁。7.7%的患者出现合并感染，其中5.1%的分离株来自尿液样本，其次2.6%来自血液。从尿液中分离出的细菌有大肠埃希菌（2.6%）、凝固酶阴性葡萄球菌（CONS）（1.3%）和肺炎克雷伯菌（1.3%）。肺炎克雷伯菌是从血液样本中分离出的唯一微生物。在鼻咽和咽喉拭子中发现混合生长，主要菌种为金黄色葡萄球菌和链球菌属。在数据收集时，55.7%的患者已接受抗菌药物治疗，30.4%的患者接受了单一抗菌药物治疗。1.3%的患者乙肝表面抗原呈阳性，无一例丙肝抗体或登革热NS1抗原呈阳性。微生物感染已被视为与SARS-CoV-2感染有关，对开具抗菌药物处方和降低住院患者的致命结局具有重要价值。
