Tafteh Nazanin, Rezaeian Shahab, Abdollahzad Hadi, Sabzi Feridoun
Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Clin Nutr Res. 2024 Jul 23;13(3):165-175. doi: 10.7762/cnr.2024.13.3.165. eCollection 2024 Jul.
This study aimed to assess the relationship between serum levels of vitamin D with anthropometric indices, lipid profile and vascular inflammatory factors, in patients who candidate for coronary artery bypass grafting (CABG). This analytical cross-sectional study was conducted in patients who were candidate for CABG. Demographic information, medical records, anthropometric indicators, blood samples, and physical activity of 150 patients were collected. 146 participants with mean ± standard deviation of age: 61.8 ± 10.0 years and body mass index: 26.9 ± 3.7 kg/m completed the study. Based on serum levels of vitamin D, patients were divided into 2 groups; groups with sufficient (≥ 30 ng/mL) and insufficient amount of vitamin D (< 30 ng/mL). The 30.14% of the patients had serum vitamin D deficiency. Ejection fraction (EF) % between the 2 groups had significant difference. Unexpectedly the EF% increased 7% in patients with insufficient level of vitamin D (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.03-1.11; p = 0.001). Vitamin D status had a significant inverse association with body weight. The odds of vitamin D deficiency significantly increased by 4% with increasing one kg in weight (OR, 1.04; 95% CI, 1-1.08; p = 0.044). There were no significant association between serum vitamin D level and intra cellular adhesion molecule-1, interleukin-17, fasting blood glucose, and lipid profile (p > 0.05). Considering the inverse association observed between serum vitamin D with EF% and body weight, vitamin D may play a role in modulating of these indices.
本研究旨在评估冠状动脉搭桥术（CABG）候选患者血清维生素D水平与人体测量指标、血脂谱及血管炎症因子之间的关系。本分析性横断面研究在CABG候选患者中进行。收集了150例患者的人口统计学信息、病历、人体测量指标、血样及身体活动情况。146名参与者完成了研究，其年龄均值±标准差为：61.8±10.0岁，体重指数为：26.9±3.7kg/m²。根据血清维生素D水平，患者被分为两组；维生素D充足组（≥30ng/mL）和维生素D不足组（<30ng/mL）。30.14%的患者存在血清维生素D缺乏。两组间的射血分数（EF）%有显著差异。出乎意料的是，维生素D水平不足的患者EF%增加了7%（优势比[OR]，1.07；95%置信区间[CI]，1.03 - 1.11；p = 0.001）。维生素D状态与体重呈显著负相关。体重每增加1kg，维生素D缺乏的几率显著增加4%（OR，1.04；95%CI，1 - 1.08；p = 0.044）。血清维生素D水平与细胞间黏附分子-1、白细胞介素-17、空腹血糖及血脂谱之间无显著关联（p>0.05）。考虑到血清维生素D与EF%和体重之间观察到的负相关关系，维生素D可能在调节这些指标中发挥作用。
