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需要通过腹股沟入路进行心脏手术的化脓性汗腺炎患者:厄他培南的病例管理

Hidradenitis suppurativa patient requiring cardiac procedure with inguinal access: Case management with ertapenem.

作者信息

Mainville Laurence, MacHaalany Jimmy, Veillette Hélène

机构信息

Division of Dermatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada.

Division of Cardiology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada.

出版信息

SAGE Open Med Case Rep. 2024 Aug 19;12:2050313X241274819. doi: 10.1177/2050313X241274819. eCollection 2024.

DOI:10.1177/2050313X241274819
PMID:39165305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334149/
Abstract

Hidradenitis suppurativa is a chronic inflammatory skin disease that usually presents in young adults with painful abscesses in intertriginous areas. We present a case of severe hidradenitis suppurativa (Hidradenitis Suppurativa Investigator Global Assessment (HS-IGA) = 5; Hurley stage III) investigated by cardiology and respirology specialists for dyspnea. The patient's symptoms required right-sided cardiac catheterization via the right femoral vein in the inguinal area. The patient was able to undergo this invasive cardiac procedure without infectious complications using multidisciplinary management (dermatology, cardiology, respirology, internal medicine, and infectious diseases specialists), intravenous ertapenem 1 g/day for 6 weeks perioperatively, biologic therapy, and treatment of diabetes with semaglutide. The administration of ertapenem preoperatively and postoperatively of an invasive procedure can be beneficial, particularly when the upcoming intervention requires access to skin areas severely affected by hidradenitis suppurativa. Comorbidities such as obesity and diabetes should be addressed as their treatment might contribute to improve hidradenitis suppurativa.

摘要

化脓性汗腺炎是一种慢性炎症性皮肤病,通常在年轻成年人的皮肤褶皱部位出现疼痛性脓肿。我们报告一例严重化脓性汗腺炎病例(化脓性汗腺炎研究者全球评估(HS-IGA)=5;Hurley Ⅲ期),因呼吸困难接受了心脏病学和呼吸病学专家的检查。患者的症状需要通过腹股沟区右侧股静脉进行右侧心导管检查。通过多学科管理(皮肤科、心脏病学、呼吸病学、内科和传染病专家),患者能够在无感染并发症的情况下接受这种侵入性心脏手术,围手术期静脉注射厄他培南1克/天,持续6周,进行生物治疗,并使用司美格鲁肽治疗糖尿病。在侵入性手术的术前和术后给予厄他培南可能是有益的,特别是当即将进行的干预需要进入受化脓性汗腺炎严重影响的皮肤区域时。肥胖和糖尿病等合并症应得到治疗,因为它们的治疗可能有助于改善化脓性汗腺炎。

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1
Hidradenitis suppurativa patient requiring cardiac procedure with inguinal access: Case management with ertapenem.需要通过腹股沟入路进行心脏手术的化脓性汗腺炎患者:厄他培南的病例管理
SAGE Open Med Case Rep. 2024 Aug 19;12:2050313X241274819. doi: 10.1177/2050313X241274819. eCollection 2024.
2
Two Cases of Hidradenitis Suppurativa Treated with Adalimumab at the Department of Dermatology and Venereology, Clinical Hospital Mostar.皮肤科和性病科在莫斯塔尔临床医院用阿达木单抗治疗两例化脓性汗腺炎。
Acta Dermatovenerol Croat. 2021 Jul;29(2):108-110.
3
Ertapenem - a potent treatment for clinical and quality of life improvement in patients with hidradenitis suppurativa.厄他培南 - 治疗化脓性汗腺炎的有效药物,可改善患者的临床症状和生活质量。
Int J Dermatol. 2018 Sep;57(9):1088-1093. doi: 10.1111/ijd.14036. Epub 2018 May 17.
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A Rare Case of Pregnancy After Surgical Treatment for Stage III Hidradenitis Suppurativa.III期化脓性汗腺炎手术治疗后妊娠1例罕见病例。
Cureus. 2023 Sep 16;15(9):e45370. doi: 10.7759/cureus.45370. eCollection 2023 Sep.
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Evidence-based approach to the treatment of hidradenitis suppurativa/acne inversa, based on the European guidelines for hidradenitis suppurativa.基于欧洲化脓性汗腺炎指南的化脓性汗腺炎/反向性痤疮循证治疗方法
Rev Endocr Metab Disord. 2016 Sep;17(3):343-351. doi: 10.1007/s11154-016-9328-5.
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Hidradenitis Suppurativa at an Uncommon Site: A Review of Its Clinical Features, Diagnostic Difficulties, and Management.罕见部位的化脓性汗腺炎:临床特征、诊断难点及治疗综述
Cureus. 2021 Oct 12;13(10):e18704. doi: 10.7759/cureus.18704. eCollection 2021 Oct.
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Secukinumab in patients with moderate-to-severe hidradenitis suppurativa based on prior biologic exposure: an efficacy and safety analysis from the SUNSHINE and SUNRISE phase III trials.基于既往生物制剂暴露情况的中重度化脓性汗腺炎患者使用司库奇尤单抗:来自 III 期 SUNSHINE 和 SUNRISE 研究的疗效和安全性分析。
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[CME Dermatology 23: Hidradenitis suppurativa].[继续医学教育皮肤科23:化脓性汗腺炎]
Praxis (Bern 1994). 2021;110(7):363-372. doi: 10.1024/1661-8157/a003693.
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[CME Dermatology 23/Answers: Hidradenitis suppurativa].[继续医学教育皮肤科23/答案:化脓性汗腺炎]
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Efficacy and Durability of Intravenous Ertapenem Therapy for Recalcitrant Hidradenitis Suppurativa.静脉注射厄他培南治疗顽固性化脓性汗腺炎的疗效和持久性。
JAMA Dermatol. 2024 Mar 1;160(3):312-318. doi: 10.1001/jamadermatol.2023.6201.

本文引用的文献

1
Efficacy and Durability of Intravenous Ertapenem Therapy for Recalcitrant Hidradenitis Suppurativa.静脉注射厄他培南治疗顽固性化脓性汗腺炎的疗效和持久性。
JAMA Dermatol. 2024 Mar 1;160(3):312-318. doi: 10.1001/jamadermatol.2023.6201.
2
Adalimumab efficacy is inversely correlated with body mass index (BMI) in hidradenitis suppurativa.阿达木单抗在化脓性汗腺炎中的疗效与体重指数(BMI)呈负相关。
Int J Dermatol. 2023 Jun;62(6):764-769. doi: 10.1111/ijd.16565. Epub 2022 Dec 29.
3
The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment.化脓性汗腺炎中的皮肤和肠道微生物群:当前的认识以及对研究和治疗的未来思考
Am J Clin Dermatol. 2022 Nov;23(6):841-852. doi: 10.1007/s40257-022-00724-w. Epub 2022 Sep 18.
4
Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations.化脓性汗腺炎的共病筛查:美国和加拿大化脓性汗腺炎基金会的循证建议
J Am Acad Dermatol. 2022 May;86(5):1092-1101. doi: 10.1016/j.jaad.2021.01.059. Epub 2021 Jan 23.
5
Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults.美国儿童和成人的化脓性汗腺炎与皮肤和皮肤外感染的相关性。
Br J Dermatol. 2020 Feb;182(2):327-334. doi: 10.1111/bjd.18093. Epub 2019 Jul 25.
6
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.北美化脓性汗腺炎临床管理指南:美国和加拿大化脓性汗腺炎基金会联合发布:第二部分:局部、皮损内和全身医学治疗。
J Am Acad Dermatol. 2019 Jul;81(1):91-101. doi: 10.1016/j.jaad.2019.02.068. Epub 2019 Mar 11.
7
Ertapenem - a potent treatment for clinical and quality of life improvement in patients with hidradenitis suppurativa.厄他培南 - 治疗化脓性汗腺炎的有效药物,可改善患者的临床症状和生活质量。
Int J Dermatol. 2018 Sep;57(9):1088-1093. doi: 10.1111/ijd.14036. Epub 2018 May 17.
8
The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls.化脓性汗腺炎患者与健康对照者的毛囊皮肤微生物群
JAMA Dermatol. 2017 Sep 1;153(9):897-905. doi: 10.1001/jamadermatol.2017.0904.
9
Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients.厄他培南治疗重度化脓性汗腺炎的疗效:对30例连续患者的队列进行的一项初步研究。
J Antimicrob Chemother. 2016 Feb;71(2):513-20. doi: 10.1093/jac/dkv361. Epub 2015 Nov 12.
10
European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.欧洲化脓性汗腺炎/反向性痤疮治疗S1指南。
J Eur Acad Dermatol Venereol. 2015 Apr;29(4):619-44. doi: 10.1111/jdv.12966. Epub 2015 Jan 30.