Medical treatment of male infertility.

None of the previously described treatments for idiopathic infertility have been shown to be effective (Table). Controlled clinical trials may indicate that certain treatments are effective in carefully selected subsets of infertile men. The key to rational therapy will be basic research leading to the elucidation of the pathophysiology of what is presently "idiopathic infertility." Our policy is to present the facts honestly and invite our patients to participate in controlled clinical trials with therapies of uncertain value.