Chowdhury Md Arifur Rahman, Haq Md Mazedul, Lee Jeong Hwan, Jeong Sangyun
Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Republic of Korea.
Department of Molecular Biology, and Research Center of Bioactive Materials, Jeonbuk National University, Jeonju, Republic of Korea.
Front Mol Neurosci. 2024 Aug 6;17:1408949. doi: 10.3389/fnmol.2024.1408949. eCollection 2024.
cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear transcription factor, which can be constitutively activated regardless of external stimuli or be inducibly activated by external factors such as stressors, hormones, neurotransmitters, and growth factors. However, CREB controls diverse biological processes including cell growth, differentiation, proliferation, survival, apoptosis in a cell-type-specific manner. The diverse functions of CREB appear to be due to CREB-mediated differential gene expression that depends on cAMP response elements and multi-faceted regulation of CREB activity. Indeed, the transcriptional activity of CREB is controlled at several levels including alternative splicing, post-translational modification, dimerization, specific transcriptional co-activators, non-coding small RNAs, and epigenetic regulation. In this review, we present versatile regulatory modes of CREB family transcription factors and discuss their functional consequences.
环磷酸腺苷反应元件结合蛋白（CREB）是一种广泛表达的核转录因子，它可以在不受外部刺激的情况下组成性激活，也可以被应激源、激素、神经递质和生长因子等外部因素诱导激活。然而，CREB以细胞类型特异性的方式控制多种生物学过程，包括细胞生长、分化、增殖、存活和凋亡。CREB的多种功能似乎归因于CREB介导的差异基因表达，这取决于环磷酸腺苷反应元件以及CREB活性的多方面调节。实际上，CREB的转录活性在多个水平受到控制，包括可变剪接、翻译后修饰、二聚化、特异性转录共激活因子、非编码小RNA和表观遗传调控。在这篇综述中，我们介绍了CREB家族转录因子的多种调控模式，并讨论了它们的功能后果。
