组胺与肠道

Histamine and the gut.

作者信息

Hirschowitz B I

出版信息

N Engl Reg Allergy Proc. 1985 Winter;6(1):21-7. doi: 10.2500/108854185779048942.

Abstract

The role of histamine in the gut is reviewed in relation to gastric secretion of acid, pepsin and intrinsic factors. Species-dependence of some of these actions are also discussed. Interactions with other agonists and antagonists in intact and isolated systems provide the basis for models of the role of histamine in control of gastric secretion. This review deals further with histamine H1 and H2 effects on gastrointestinal circulation and musculature including sphincters. The most dramatic application of the development of histamine H2 antagonists has been in the treatment of duodenal ulcer. The use of H2 antagonists in the treatment of duodenal and gastric ulcer, gastrinoma, gastritis, and esophagitis is critically evaluated.

摘要

本文综述了组胺在肠道中与胃酸、胃蛋白酶和内因子分泌的关系。文中还讨论了这些作用的种属依赖性。组胺在完整和分离系统中与其他激动剂和拮抗剂的相互作用为组胺在胃酸分泌控制中作用的模型提供了基础。本文进一步探讨了组胺H1和H2对胃肠道循环及包括括约肌在内的肌肉组织的作用。组胺H2拮抗剂研发最显著的应用是在十二指肠溃疡的治疗中。文中对H2拮抗剂在十二指肠溃疡、胃溃疡、胃泌素瘤、胃炎和食管炎治疗中的应用进行了批判性评估。