Göçer Gürok Neşe, Demir Betül, Atmaca Murad
Department of Dermatology, Fethi Sekin City Hospital, Elazığ, Türkiye.
Department of Dermatology, Fırat University, Faculty of Medicine, Elazığ, Türkiye.
Psychiatry Clin Psychopharmacol. 2024 Jun 1;34(2):163-171. doi: 10.5152/pcp.2024.23718. eCollection 2024 Jun.
Previous studies have demonstrated that lipids could play a role in suicidal ideation and the pathogenesis of psychiatric diseases. The present study aims to investigate the correlation between variations in serum lipid concentration, a side effect of isotretinoin (ITT), psychiatric symptoms, and suicidal ideation in acne vulgaris patients under ITT treatment.
Thestudy was completed with 41 acne patients. Patients were analyzed with the sociodemographic and clinical data form, Beck depression inventory (BDI), Beck anxiety inventory (BAI), Beck Suicidal Ideation Scale (BSS), and Brief Psychiatric Rating Scale (BPRS) at the beginning and on the third month of treatment. Lipid levels [serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL)] were measured using the automatic chemistry analyzer (Beckman AU-5800). Serum low-density lipoprotein cholesterol (LDL) values were estimated with the Friedewald formula.
A statistically significant correlation was determined between the BSS scores and TC, TG, and LDL parameters at the beginning of treatment and the control date. Thus, it was determined that there was a negative weak correlation between BSS and TC parameters ( = -0.403; = .009), a moderate negative correlation between BSS and TG ( = -0.526; < .001), and a weak negative correlation between BSS and LDL ( = -0.421; = .006). Furthermore, there were statistically significant changes between the BDI and BAI scores at the beginning of treatment and the third month ( = 0.016 and = .001, respectively). Although an increase was observed in BSS and BPRS after the treatment compared to pretreatment, the increase was not statistically significant.
The present study findings revealed that serum lipid levels could be associated with psychiatric side effects in patients under ITT treatment. But, this must not be the only way to detect the risk when we consider that serum lipid levels that have been associated with suicidal ideation, depression, and several psychiatric diseases have the potential to be an important indicator. In this context, our preliminary results open the doors to a new perspective in this regard, using the concept of blood lipid optimization. These findings need to be considered preliminary and supported by large samples.
先前的研究表明，脂质可能在自杀意念及精神疾病的发病机制中发挥作用。本研究旨在调查异维A酸（ITT）治疗寻常痤疮患者时，血清脂质浓度变化、精神症状和自杀意念之间的相关性。
该研究纳入41例痤疮患者。在治疗开始时及治疗第三个月，使用社会人口统计学和临床数据表格、贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、贝克自杀意念量表（BSS）和简明精神病评定量表（BPRS）对患者进行分析。使用自动化学分析仪（贝克曼AU-5800）测量血脂水平[血清总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL）]。血清低密度脂蛋白胆固醇（LDL）值采用Friedewald公式估算。
在治疗开始时和对照日期，BSS评分与TC、TG和LDL参数之间存在统计学显著相关性。因此，确定BSS与TC参数之间存在弱负相关（r = -0.403；p = 0.009），BSS与TG之间存在中度负相关（r = -0.526；p < .001），BSS与LDL之间存在弱负相关（r = -0.421；p = 0.006）。此外，治疗开始时和第三个月的BDI和BAI评分之间存在统计学显著变化（分别为p = 0.016和p = 0.001）。尽管与治疗前相比，治疗后BSS和BPRS有所增加，但增加无统计学显著性。
本研究结果表明，ITT治疗患者的血清脂质水平可能与精神副作用有关。但是，当我们考虑到与自杀意念、抑郁和几种精神疾病相关的血清脂质水平有可能成为一个重要指标时，这不一定是检测风险 的唯一方法。在此背景下，我们的初步结果为利用血脂优化概念在这方面开辟了一个新的视角。这些发现需要被视为初步结果，并得到大样本的支持。
