Sun Meng, Bai Jiangtao, Wang Haisong, Li Mei, Zhou Long, Li Shanfeng
Department of Interventional Vascular Surgery, Affiliated Hospital of Hebei University, Baoding, China.
Heliyon. 2024 Jul 29;10(15):e35306. doi: 10.1016/j.heliyon.2024.e35306. eCollection 2024 Aug 15.
This study intended to determine the molecular subtypes of liver hepatocellular carcinoma (LIHC) on the strength of anoikis-related genes (ARGs) and to assess their prognostic value and prospective relationship with immune cell infiltration and cancer-associated fibroblasts (CAFs). Univariate Cox regression analysis yielded 66 prognosis-related ARGs and classified LIHC into two distinct subtypes, with subtype A demonstrating overexpression of most prognosis-related ARGs and a significant survival disadvantage. Furthermore, a reliable prediction model was developed using ARGs to evaluate the risk of LIHC patients. This model served as an independent prognostic indicator and a quantitative tool for clinical prognostic prediction. Additionally, subtype-specific differences in immune cell infiltration were observed, and the risk score was potentially linked to immune-related characteristics. Moreover, the study identified a significant association between CAF score and LIHC prognosis, with a low CAF score indicating a favorable patient prognosis. In conclusion, this study reveals the molecular mechanisms underlying the development and progression of LIHC and identifies potential therapeutic targets for the disease.
本研究旨在基于失巢凋亡相关基因（ARGs）确定肝细胞癌（LIHC）的分子亚型，并评估其预后价值以及与免疫细胞浸润和癌症相关成纤维细胞（CAFs）的潜在关系。单因素Cox回归分析产生了66个与预后相关的ARGs，并将LIHC分为两种不同的亚型，其中A型显示大多数与预后相关的ARGs过表达且具有显著的生存劣势。此外，利用ARGs开发了一个可靠的预测模型来评估LIHC患者的风险。该模型可作为独立的预后指标和临床预后预测的定量工具。此外，观察到免疫细胞浸润存在亚型特异性差异，且风险评分可能与免疫相关特征有关。此外，该研究确定了CAF评分与LIHC预后之间存在显著关联，低CAF评分表明患者预后良好。总之，本研究揭示了LIHC发生发展的分子机制，并确定了该疾病的潜在治疗靶点。
