Wang Hongyu, Yang Yawen, Zhang Gan, Yang Guang, Wang Ying, Liu Lu, Du Juan
Department of Abdominal Oncology, Jilin Cancer Hospital, Changchun, 130000, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 4. doi: 10.1007/s00210-025-04088-w.
As the fourth leading cause of death from cancer and the sixth most common neoplasm in the world, hepatocellular carcinoma (HCC) is responsible for ninety percent of all primary liver cancers. There are four mechanisms that contribute to the spread of cancer: the separation of cells from the primary neoplasm, their survivability during metastasis, extravasation, and the development of secondary tumors at remote locations. In addition to its role in the development of a scaffold for cell adhesion, the extracellular matrix (ECM) also plays a role in the stimulation of signal transduction and the regulation of essential cellular mechanisms, including proliferation, migration, differentiation, and viability. The disruption of cell-ECM interactions and the ensuing separation of cells from the primary ECM trigger anoikis, a form of programmed cell death. One of the most effective factors in suppressing anoikis is ECM receptors from the integrin family. Cell migration, proliferation, and survival are primarily governed by the formation of physical connections with the cytoskeleton and the conveyance of signals between cells and the ECM via integrin receptors.
作为全球第四大致癌死亡原因和第六大常见肿瘤，肝细胞癌（HCC）占所有原发性肝癌的90%。癌症扩散有四种机制：细胞从原发性肿瘤分离、转移过程中的生存能力、外渗以及在远处形成继发性肿瘤。细胞外基质（ECM）除了在构建细胞黏附支架中发挥作用外，还在刺激信号转导和调节基本细胞机制（包括增殖、迁移、分化和生存能力）方面发挥作用。细胞与ECM相互作用的破坏以及随之而来的细胞与原发性ECM的分离会引发失巢凋亡，这是一种程序性细胞死亡形式。抑制失巢凋亡最有效的因素之一是整合素家族的ECM受体。细胞迁移、增殖和存活主要由与细胞骨架形成物理连接以及通过整合素受体在细胞与ECM之间传递信号来控制。
