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中风后右侧脑损伤所致失语症的间歇性θ波爆发刺激：一项为期2年随访的病例报告

Intermittent theta-burst stimulation in aphasia caused by right side cerebral lesions after stroke: A case report with 2-year follow-up.

作者信息

Li Haozheng, Fan Shunjuan, Wu Yi, Fang Dongxiang, Hu Ruiping, Lu Rongrong

机构信息

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 200040, Shanghai, China.

National Center for Neurological Disorders, 20040, Shanghai, China.

出版信息

Heliyon. 2024 Jul 25;10(15):e35206. doi: 10.1016/j.heliyon.2024.e35206. eCollection 2024 Aug 15.

DOI:10.1016/j.heliyon.2024.e35206
PMID:39166089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11333899/
Abstract

BACKGROUND AND OBJECTIVES

This case report investigates the application of intermittent Theta-Burst Stimulation (iTBS) in aphasia rehabilitation following a right hemisphere stroke.

CASE PRESENTATION

A 52-year-old Chinese male with Broca's aphasia post-stroke was treated with iTBS. His progress was evaluated using Functional Near-Infrared Spectroscopy (fNIRS) and behavioral assessments. Significant language function improvement was noted, with fNIRS showing increased activation in right hemisphere language-related cortical areas and altered functional connectivity patterns.

CONCLUSION

The findings indicate that iTBS is effective in facilitating language recovery in right hemisphere stroke-induced aphasia, highlighting the importance of personalized neurorehabilitation strategies. Despite focusing on a single case, the study contributes to understanding neural plasticity mechanisms in right hemisphere stroke-induced aphasia.

摘要

背景与目的

本病例报告研究间歇性theta波爆发刺激（iTBS）在右半球中风后失语症康复中的应用。

病例介绍

一名52岁的中国男性中风后患有布罗卡失语症，接受了iTBS治疗。使用功能近红外光谱（fNIRS）和行为评估对其进展进行评估。结果显示语言功能有显著改善，fNIRS表明右半球语言相关皮质区域的激活增加，功能连接模式改变。

结论

研究结果表明iTBS在促进右半球中风引起的失语症语言恢复方面有效，突出了个性化神经康复策略的重要性。尽管该研究聚焦于单个病例，但有助于理解右半球中风引起的失语症中的神经可塑性机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/0c1c30f6159c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/c9e16a6b63bf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/d80d4c3814f7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/0c1c30f6159c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/c9e16a6b63bf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/d80d4c3814f7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf3/11333899/0c1c30f6159c/gr3.jpg

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本文引用的文献

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Language reorganization patterns in global aphasia-evidence from fNIRS.全球失语症中的语言重组模式——来自功能近红外光谱的证据
Front Neurol. 2023 Jan 6;13:1025384. doi: 10.3389/fneur.2022.1025384. eCollection 2022.
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Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia.运用聚类分析对脑卒中后失语症西方失语症成套测验的失语商进行分析，以确定语言缺陷程度。
Sci Rep. 2022 Sep 6;12(1):15108. doi: 10.1038/s41598-022-17997-0.
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Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper.
经颅磁刺激的脑刺激：刺激的是什么？——共识与关键立场文件。
Clin Neurophysiol. 2022 Aug;140:59-97. doi: 10.1016/j.clinph.2022.04.022. Epub 2022 May 18.
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Reliability of theta burst stimulation as a neuromodulation tool.theta 爆发刺激作为神经调节工具的可靠性。
J Neurophysiol. 2022 Jun 1;127(6):1532-1534. doi: 10.1152/jn.00507.2021. Epub 2022 May 11.
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Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis.经颅磁刺激对脑卒中患者皮质兴奋性调节作用的系统评价和荟萃分析。
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