Marni A, Ferrero M E
Istituto di Patologia Generale, C.N.R., Milano, Italy.
Life Support Syst. 1985;3 Suppl 1:649-53.
There is still no reliable early indicator of pancreatic rejection. This constitutes the main reason why many groups favor simultaneous kidney and pancreas transplantation on the assumption that pancreatic rejection may be treated in time by monitoring the renal allograft course. To provide an experimental model to investigate this problem, we have developed a technique of simultaneous kidney and pancreas transplantation in the rat. In isografts functional evaluation of the grafted organs was performed by testing blood glucose, serum insulin, blood urea and intravenous GTT. Our results demonstrated that functional and histological evaluations of kidney and pancreas simultaneously grafted in rats were well maintained up to 9 months and were similar to those revealed in kidney or pancreas isografted alone. The experimental model of simultaneous kidney and pancreas transplantation here described appears useful to study pancreatic rejection in allograft combinations as well as for testing immunosuppressive treatments.
目前仍没有可靠的胰腺排斥早期指标。这就是许多研究小组倾向于同时进行肾胰腺移植的主要原因，他们认为通过监测肾移植的过程可以及时治疗胰腺排斥反应。为了提供一个研究该问题的实验模型，我们开发了一种大鼠同时肾胰腺移植技术。在同基因移植中，通过检测血糖、血清胰岛素、血尿素和静脉葡萄糖耐量试验对移植器官进行功能评估。我们的结果表明，同时移植到大鼠体内的肾脏和胰腺，其功能和组织学评估在长达9个月的时间里都保持良好，与单独进行肾脏或胰腺同基因移植的情况相似。本文所描述的同时肾胰腺移植实验模型，似乎有助于研究同种异体移植组合中的胰腺排斥反应，以及测试免疫抑制治疗方法。
