van Goor H, Sluiter W J, Wijffels R T, Slooff M J
University Hospital Groningen, the Netherlands.
Life Support Syst. 1985;3 Suppl 1:701-6.
It is hypothesized that heterotopic segmental pancreatic autotransplantation with removal of the remaining segment compromises glucose tolerance in dogs in the long run. In 10 dogs the left lobe of the pancreas was heterotopically autotransplanted, in 5 dogs the left lobe remained in situ, after denervation. Duct drainage was provided by a pancreaticoileostomy. Six months after transplantation, decreased beta-cell response, combined with increased insulin sensitivity was observed in the heterotopically transplanted dogs. Five dogs in this group developed an insulin dependent diabetes mellitus. These results are explicable by the diversion of insulin from the liver and the late effects of continuous endocrine pancreatic stimulation on the beta-cell function.
据推测，长期来看，切除剩余胰腺节段后进行异位节段性胰腺自体移植会损害犬类的葡萄糖耐量。在10只犬中，将胰腺左叶进行了异位自体移植，5只犬在去神经支配后，胰腺左叶保留原位。通过胰管回肠吻合术进行导管引流。移植6个月后，在异位移植的犬中观察到β细胞反应降低，同时胰岛素敏感性增加。该组中有5只犬发展为胰岛素依赖型糖尿病。这些结果可以通过胰岛素从肝脏的分流以及胰腺持续内分泌刺激对β细胞功能的后期影响来解释。
