鼻前庭表型内变异对局部气流动力学的影响。
Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.
作者信息
Sicard Ryan, Russel Sarah, Jang David, Hachem Ralph Abi, Frank-Ito Dennis O
机构信息
Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Durham, North Carolina, U.S.A.
Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.
出版信息
Laryngoscope. 2025 Jan;135(1):50-58. doi: 10.1002/lary.31688. Epub 2024 Aug 21.
OBJECTIVES
Many individuals with healthy normal nasal anatomy and function exhibit a prominent notch indentation at the junction of the ala and sidewall, specifically around the anterior-superior region of the unilateral nasal vestibule up to the internal nasal valve. This study evaluates the influence of various sizes of notched indentations at the anterior nasal airway on local airflow pattern.
METHODS
A retrospective study involving 25 healthy individuals, each exhibiting at least one unilateral notched indentation (40 total airways). Each individual's notched indentation was quantified after subject-specific three-dimensional nasal airway reconstruction from radiographic images. Computational fluid dynamics modeling was used to simulate nasal inspiratory airflow in each nasal airway at 15 L/min. Localized airflow distributions passing through the inferior, middle, and superior regions were calculated at 15 cross sections.
RESULTS
Notched indentation size ranged 1.75-86.84 mm (average = 22.37 mm). At the anterior airway, notched size significantly correlated with inferior airflow volume (R = 0.32, p = 0.04) but not in the middle (R = 0.21, p = 0.20) or superior (R = 0.06, p = 0.70) regions, whereas middle and superior regional resistance values were significantly correlated with notched size (middle: R = 0.54, p < 0.001; superior: R = 0.41, p = 0.009). Medially, resistance at the middle region significantly correlated with notched size (R = 0.56, p < 0.001). At the posterior airway, airflow distributions through the inferior, middle, and superior regions demonstrated weak correlation with notched size (inferior: R = 0.24, p = 0.14, middle: R = 0.24, p = 0.13; superior:R = 0.03, p = 0.83), whereas resistance was significantly correlated in the middle and inferior regions (middle: R = 0.56, p < 0.001;inferior: R = 0.43, p = 0.006).
CONCLUSIONS
Anterior nasal airway notched indentation size had significantly stronger influence on localized airflow volume through the anterior-inferior airway than other regions of the nasal passage.
LEVEL OF EVIDENCE
NA Laryngoscope, 135:50-58, 2025.
目的
许多鼻腔解剖结构和功能正常的个体在鼻翼与鼻侧壁交界处，特别是单侧鼻前庭的前上区域直至鼻内阀处，会出现明显的切迹凹陷。本研究评估鼻前气道不同大小的切迹凹陷对局部气流模式的影响。
方法
一项回顾性研究，纳入25名健康个体，每人至少有一个单侧切迹凹陷（共40个气道）。在根据影像学图像进行个体特异性三维鼻气道重建后，对每个个体的切迹凹陷进行量化。采用计算流体动力学建模，以15升/分钟的流速模拟每个鼻气道的鼻吸气气流。在15个横截面处计算通过下、中、上区域的局部气流分布。
结果
切迹凹陷大小范围为1.75 - 86.84毫米（平均 = 22.37毫米）。在前气道，切迹大小与下气流体积显著相关（R = 0.32，p = 0.04），但与中气流体积（R = 0.21，p = 0.20）或上气流体积（R = 0.06，p = 0.70）无关，而中、上区域的阻力值与切迹大小显著相关（中：R = 0.54，p < 0.001；上：R = 0.41，p = 0.009）。在内侧，中区域的阻力与切迹大小显著相关（R = 0.56，p < 0.001）。在后气道，通过下、中、上区域的气流分布与切迹大小的相关性较弱（下：R = 0.24，p = 0.14；中：R = 0.24，p = 0.13；上：R = 0.03，p = 0.83），而中、下区域的阻力与切迹大小显著相关（中：R = 0.56，p < 0.001；下：R = 0.43，p = 0.006）。
结论
鼻前气道切迹凹陷大小对通过前下气道的局部气流量的影响明显强于鼻道的其他区域。
证据水平
NA 喉镜，135:50 - 58，2025年。
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