Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, People's Republic of China.
Eur J Endocrinol. 2024 Aug 5;191(2):262-270. doi: 10.1093/ejendo/lvae087.
Previous studies focusing on primary aldosteronism (PA) and thyroid diseases were controversial. Hence, this study aimed to examine associations between thyroid function, thyroid diseases, and PA and its subtypes.
This was a cross-sectional study, which enrolled 1023 patients with PA and 6138 patients with essential hypertension (EH) admitted to Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region from August 2011 to June 2022. All patients with PA were accurately classified into aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) by adrenal vein sampling (AVS). Multivariate logistic regression analysis was used to assess the relationship of thyroid function, thyroid nodules, and PA and its subtypes.
A total of 7161 patients (327 APA and 696 IHA, and 6138 EH) were included with a mean age of 48.20 ± 8.83 years. PA patients and PA subtypes showed lower FT4, FT3, TT4, TT3, and prevalence of positive TPOAb, meanwhile higher prevalence of thyroid nodules than EH patients (PA: 56.10%, IHA: 56.90%, APA: 54.80%, and EH: 48.90%, respectively). PA (adjusted OR: 1.290, 95% CI: 1.035-1.607, P = .02) and its subtype (IHA) (adjusted OR: 1.316, 95% CI: 1.005-1.724, P = .04) were significantly associated with thyroid nodules. Compared to patients with lower plasma aldosterone concentration (PAC) levels (<12 ng/dL), patients with PAC levels ≥ 12 ng/dL presented a higher prevalence of thyroid nodules.
PA patients had lower thyroid function and higher prevalence of thyroid nodules compared to EH patients. Therefore, the screening of thyroid function and thyroid nodules may be indispensable for PA patients.
以前关于原发性醛固酮增多症（PA）和甲状腺疾病的研究存在争议。因此，本研究旨在探讨甲状腺功能、甲状腺疾病与 PA 及其亚型之间的关系。
这是一项横断面研究，纳入了 2011 年 8 月至 2022 年 6 月期间新疆维吾尔自治区人民医院高血压中心收治的 1023 例 PA 患者和 6138 例原发性高血压（EH）患者。所有 PA 患者均通过肾上腺静脉取样（AVS）准确分为醛固酮瘤（APA）和特发性醛固酮增多症（IHA）。采用多变量逻辑回归分析评估甲状腺功能、甲状腺结节与 PA 及其亚型的关系。
共纳入 7161 例患者（327 例 APA、696 例 IHA 和 6138 例 EH），平均年龄为 48.20±8.83 岁。PA 患者和 PA 亚型的 FT4、FT3、TT4、TT3 水平较低，TPOAb 阳性率较高，甲状腺结节检出率也高于 EH 患者（PA：56.10%、IHA：56.90%、APA：54.80%和 EH：48.90%）。PA（调整后的 OR：1.290，95%CI：1.035-1.607，P=0.02）及其亚型（IHA）（调整后的 OR：1.316，95%CI：1.005-1.724，P=0.04）与甲状腺结节显著相关。与较低的血浆醛固酮浓度（PAC）水平（<12ng/dL）患者相比，PAC 水平≥12ng/dL 的患者甲状腺结节检出率更高。
与 EH 患者相比，PA 患者甲状腺功能较低，甲状腺结节检出率较高。因此，PA 患者筛查甲状腺功能和甲状腺结节可能是不可或缺的。
