使用冷冻的天然粪便进行复发性感染的粪便微生物群移植：一种提高供体粪便准备效率的简单方法。
Use of frozen native feces for fecal microbiota transplantation in recurrent infection: a simple way to improve the efficiency of donor feces preparation.
机构信息
Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.
Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.
出版信息
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0073424. doi: 10.1128/aac.00734-24. Epub 2024 Aug 21.
Abstract
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
摘要
制备粪便微生物群移植（FMT）供体样本后立即进行移植的方式资源消耗大，而且一部分供体样本会因为异常的筛查结果而被销毁。我们回顾性比较了两种方法，即冷冻粪便准备（FFP）和新鲜冷冻原生粪便准备（FNFP），以评估它们在治疗复发性感染（rCDI）中的临床疗效。FFP 和 FNFP 的临床成功率分别为 76.7%和 86.7%（=0.32），二者疗效相当。FNFP 是一种有效的方法，在保持 rCDI 临床疗效的同时节约了资源。
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