使用冷冻的天然粪便进行复发性感染的粪便微生物群移植：一种提高供体粪便准备效率的简单方法。
Use of frozen native feces for fecal microbiota transplantation in recurrent infection: a simple way to improve the efficiency of donor feces preparation.
机构信息
Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France.
Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France.
出版信息
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0073424. doi: 10.1128/aac.00734-24. Epub 2024 Aug 21.
Abstract
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
摘要
制备粪便微生物群移植（FMT）供体样本后立即进行移植的方式资源消耗大，而且一部分供体样本会因为异常的筛查结果而被销毁。我们回顾性比较了两种方法，即冷冻粪便准备（FFP）和新鲜冷冻原生粪便准备（FNFP），以评估它们在治疗复发性感染（rCDI）中的临床疗效。FFP 和 FNFP 的临床成功率分别为 76.7%和 86.7%（=0.32），二者疗效相当。FNFP 是一种有效的方法，在保持 rCDI 临床疗效的同时节约了资源。
相似文献
1
Use of frozen native feces for fecal microbiota transplantation in recurrent infection: a simple way to improve the efficiency of donor feces preparation.
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0073424. doi: 10.1128/aac.00734-24. Epub 2024 Aug 21.
2
Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile).
Cochrane Database Syst Rev. 2023 Apr 25;4(4):CD013871. doi: 10.1002/14651858.CD013871.pub2.
3
Host origin of microbiota drives functional recovery and clearance in mice.
mBio. 2025 Jun 2:e0110825. doi: 10.1128/mbio.01108-25.
4
Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS.
Inflamm Bowel Dis. 2025 Jan 25. doi: 10.1093/ibd/izae291.
5
Fecal Microbiome Transplantation for Recurrent CDI: Treatment Efficacy and Safety with Oral Capsules.
J Gastrointestin Liver Dis. 2025 Jun 28;34(2):199-204. doi: 10.15403/jgld-5990.
6
Lyophilised fecal microbiota transfer in capsules for recurrent Clostridioides difficile infection.
Int J Antimicrob Agents. 2025 Oct;66(4):107561. doi: 10.1016/j.ijantimicag.2025.107561. Epub 2025 Jul 1.
7
Faecal microbiota transplantation for recurrent Clostridiodes difficile infection & its global regulatory landscape.
Indian J Med Res. 2025 Feb;161(2):113-119. doi: 10.25259/IJMR_818_2024.
8
Fecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic review.
J Clin Gastroenterol. 2014 Sep;48(8):693-702. doi: 10.1097/MCG.0000000000000046.
9
Systematic review with meta-analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection.
Aliment Pharmacol Ther. 2017 Sep;46(5):479-493. doi: 10.1111/apt.14201. Epub 2017 Jul 14.
10
Fecal microbiota live - jslm (Rebyota™/RBL) for management of recurrent infection.
Future Microbiol. 2024;19(14):1243-1251. doi: 10.1080/17460913.2024.2364583. Epub 2024 Jul 11.
引用本文的文献
1
Fecal Microbiota Transplantation (FMT) in Clostridium difficile Infection: A Paradigm Shift in Gastrointestinal Microbiome Modulation.
Cureus. 2025 May 29;17(5):e85054. doi: 10.7759/cureus.85054. eCollection 2025 May.
本文引用的文献
1
Effect of cryopreservation medium conditions on growth and isolation of gut anaerobes from human faecal samples.
Microbiome. 2022 May 30;10(1):80. doi: 10.1186/s40168-022-01267-2.
2
Faecal microbiota transplantation for recurrent infection: An updated systematic review and meta-analysis.
EClinicalMedicine. 2020 Nov 23;29-30:100642. doi: 10.1016/j.eclinm.2020.100642. eCollection 2020 Dec.
3
Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):67-80. doi: 10.1038/s41575-020-0350-4. Epub 2020 Aug 25.
4
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study.
Gut. 2020 May;69(5):859-867. doi: 10.1136/gutjnl-2019-319630. Epub 2019 Dec 18.
5
International consensus conference on stool banking for faecal microbiota transplantation in clinical practice.
Gut. 2019 Dec;68(12):2111-2121. doi: 10.1136/gutjnl-2019-319548. Epub 2019 Sep 28.
6
A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation.
Sci Rep. 2019 Jun 20;9(1):8897. doi: 10.1038/s41598-019-45173-4.
7
Efficacy of different faecal microbiota transplantation protocols for infection: A systematic review and meta-analysis.
United European Gastroenterol J. 2018 Oct;6(8):1232-1244. doi: 10.1177/2050640618780762. Epub 2018 Jun 3.
8
European consensus conference on faecal microbiota transplantation in clinical practice.
Gut. 2017 Apr;66(4):569-580. doi: 10.1136/gutjnl-2016-313017. Epub 2017 Jan 13.
9
Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection.
Gastroenterology. 2017 Mar;152(4):799-811.e7. doi: 10.1053/j.gastro.2016.11.010. Epub 2016 Nov 17.
10
Understanding the mechanisms of faecal microbiota transplantation.
Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):508-16. doi: 10.1038/nrgastro.2016.98. Epub 2016 Jun 22.
Zotero 插件