Gallinger Anja, Osei-Davies Rahman, Hennersdorf F
Klinik für Innere Medizin, Kardiologie und Angiologie, Schön Klinik Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland.
Inn Med (Heidelb). 2024 Dec;65(12):1266-1269. doi: 10.1007/s00108-024-01768-2. Epub 2024 Aug 21.
The case of a 72-year-old female patient with arrhythmogenic syncope associated with a combination therapy of flecainide and lacosamide is presented. The authors believe in an additive effect of both drugs on myocardial voltage-gated sodium channels with extraordinary QRS widening, exit block with temporary pacing and complete reversibility through infusion of sodium bicarbonate as bail-out therapy.
本文介绍了一名72岁女性患者的病例,该患者患有致心律失常性晕厥,与氟卡尼和拉科酰胺联合治疗有关。作者认为这两种药物对心肌电压门控钠通道具有累加效应,导致QRS波异常增宽、临时起搏时出现传出阻滞,以及通过输注碳酸氢钠作为补救治疗可完全逆转。