Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Ramapuram, Chennai, Tamil Nadu, 600089, India.
Life Science Division, Faculty of Health and Life Sciences, INTI International University, 71800, Nilai, Malaysia.
Environ Geochem Health. 2024 Aug 21;46(10):386. doi: 10.1007/s10653-024-02154-5.
In the era dominated by plastic, the widespread use of plastic in our daily lives has led to a growing accumulation of its degraded byproducts, such as microplastics and plastic additives like Bisphenol A (BPA). BPA is recognized as one of the earliest man-made substances that exhibit endocrine-disrupting properties. It is frequently employed in the manufacturing of epoxy resins, polycarbonates, dental fillings, food storage containers, infant bottles, and water containers. BPA is linked to a range of health issues including obesity, diabetes, chronic respiratory illnesses, cardiovascular diseases, and reproductive abnormalities. This study examines the bacterial bioremediation of the BPA, which is found in many sources and is known for its hazardous effects on the environment. The metabolic pathways for the breakdown of BPA in important bacterial strains were hypothesized based on the observed altered intermediate metabolites during the degradation of BPA. This review discusses the enzymes and genes involved in the bacterial degradation of BPA. The utilization of naturally occurring microorganisms is the most efficient and cost-effective method due to their selectivity of strains, ensuring sustainability.
在塑料时代，塑料在我们日常生活中的广泛使用导致其降解副产物（如微塑料和塑料添加剂如双酚 A（BPA））的积累日益增多。BPA 被认为是最早具有内分泌干扰特性的人造物质之一。它常用于制造环氧树脂、聚碳酸酯、牙填充材料、食品储存容器、婴儿奶瓶和水瓶。BPA 与一系列健康问题有关，包括肥胖、糖尿病、慢性呼吸道疾病、心血管疾病和生殖异常。本研究考察了 BPA 的细菌生物修复，BPA 存在于许多来源中，已知对环境有危险影响。根据 BPA 降解过程中观察到的中间代谢物的变化，假设了重要细菌菌株中 BPA 分解的代谢途径。本综述讨论了参与 BPA 细菌降解的酶和基因。由于天然存在的微生物对菌株的选择性，利用它们是最有效和最具成本效益的方法，确保了可持续性。
