Deeg Dorly J H, Hoogendijk Emiel O, van Schoor Natasja M, Schaap Laura A, Lima Passos Valéria
Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute/Ageing and Later Life Program, Amsterdam University Medical Centers - Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Faculty of Science, Department of Health Sciences, Amsterdam Public Health Research Institute/Ageing and Later Life program, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
J Aging Health. 2025 Oct;37(9):507-516. doi: 10.1177/08982643241273298. Epub 2024 Aug 21.
BackgroundThe well-known disablement process has been conceptualized as a series of transitions between progressive states of functional decline. We studied joint patterns of change within disablement states defined as walking speed, grip strength, and self-reported disability.Methods1702 participants aged 65 and over were included from the Longitudinal Aging Study Amsterdam, spanning seven waves over 20 years (1996-2016). Group-based multi-trajectory modeling yielded trajectory clusters (TCs) of different patterns of change, further characterized by baseline sociodemographic characteristics, physical and cognitive health, and survival rate.ResultsFive TCs were identified, distinguished by increasing baseline age. Walking speed and disability showed generally concomitant trajectories. Women had poorer trajectories in grip strength than men, but not in walking speed and disability. Poor physical health distinguished especially the poorest, and cognitive impairment distinguished especially the one-before-poorest from the better TCs.DiscussionThe findings suggest that the disablement states are not generally distinct or sequential.
背景
著名的失能过程已被概念化为功能衰退渐进状态之间的一系列转变。我们研究了定义为步行速度、握力和自我报告的残疾等失能状态下的联合变化模式。
方法
从阿姆斯特丹纵向老龄化研究中纳入了1702名65岁及以上的参与者,该研究跨越20年(1996 - 2016年)的七个波次。基于组的多轨迹建模产生了不同变化模式的轨迹簇(TCs),并通过基线社会人口学特征、身体和认知健康以及生存率进一步表征。
结果
识别出五个轨迹簇,以基线年龄增加为特征。步行速度和残疾状况通常呈现伴随轨迹。女性在握力方面的轨迹比男性差,但在步行速度和残疾方面并非如此。身体健康状况差尤其区分出最差的轨迹簇,认知障碍尤其区分出次差的轨迹簇与较好的轨迹簇。
讨论
研究结果表明,失能状态通常并非截然不同或依次出现。