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基于具有全国代表性的横断面 H-UNCOVER 研究,匈牙利诊断和未诊断糖尿病的流行情况及其决定因素。

Prevalence and determinants of diagnosed and undiagnosed diabetes in Hungary based on the nationally representative cross-sectional H-UNCOVER study.

机构信息

Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, Üllői út 26, Budapest H-1085, Hungary.

Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Üllői út 26, Budapest H-1085, Hungary.

出版信息

Diabetes Res Clin Pract. 2024 Oct;216:111834. doi: 10.1016/j.diabres.2024.111834. Epub 2024 Aug 19.

Abstract

AIMS

To estimate prevalence of diagnosed (dDM) and undiagnosed diabetes (uDM) in Hungary and investigate determinants of uDM.

METHODS

Data was obtained from the nationally representative H-UNCOVER study. As laboratory measurements were available for 11/19 Hungarian counties, n = 5,974/17,787 people were eligible. After exclusions, 5,673 (representing 4,976,097 people) were included. dDM was defined by self-reporting, while uDM as negative self-reporting and elevated fasting glucose (≥7 mmol/l) and/or HbA1c (≥48 mmol/mol). Logistic regression for complex samples was used to calculate comparisons between dDM and uDM adjusted for age and BMI.

RESULTS

Diabetes prevalence was 12.0 %/11.9 % (women/men, 95 %CI:10.7-13.4 %/10.7-13.2 %), while 2.2 %/2.8 % (1.7-2.8 %/2.2-3.6 %) of women/men were uDM. While the proportion of uDM vs. dDM was similar for women ≥ 40, men in their forties had the highest odds for uDM. Neither unemployment (women/men OR:0.58 [0.14-2.45]/0.50 [0.13-1.92]), nor education level (tertiary vs. primary; women/men OR: 1.16 [0.53-2.56]/ 0.53 [0.24-1.18]) were associated with uDM. The risk of uDM was lower in both sexes with chronic morbidities.

CONCLUSIONS

We report higher prevalence of diabetes and undiagnosed diabetes than previous Hungarian estimates. The finding that socioeconomic factors are not associated to uDM suggests that universal health care could provide equitable access to diabetes diagnosis.

摘要

目的

估计匈牙利已诊断糖尿病(dDM)和未诊断糖尿病(uDM)的患病率,并探讨 uDM 的决定因素。

方法

数据来自具有全国代表性的 H-UNCOVER 研究。由于实验室测量可用于 19 个匈牙利县中的 11 个,因此符合条件的人数为 5974/17787。排除后,共纳入 5673 人(代表 4976097 人)。dDM 通过自我报告定义,而 uDM 则为自我报告阴性且空腹血糖升高(≥7mmol/l)和/或 HbA1c(≥48mmol/mol)。使用复杂样本的逻辑回归计算了调整年龄和 BMI 后 dDM 与 uDM 之间的比较。

结果

糖尿病患病率为 12.0%/11.9%(女性/男性,95%CI:10.7-13.4%/10.7-13.2%),而女性/男性中 2.2%/2.8%(1.7-2.8%/2.2-3.6%)为 uDM。虽然女性≥40 岁者的 uDM 比例与 dDM 相似,但 40 多岁的男性患 uDM 的可能性最高。失业(女性/男性 OR:0.58[0.14-2.45]/0.50[0.13-1.92])和教育程度(高等教育与小学教育;女性/男性 OR:1.16[0.53-2.56]/0.53[0.24-1.18])均与 uDM 无关。两种性别患有慢性疾病的 uDM 风险均较低。

结论

我们报告的糖尿病和未诊断糖尿病的患病率高于匈牙利以前的估计。社会经济因素与 uDM 无关的发现表明,全民健康保险可以为糖尿病诊断提供公平的机会。

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