Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, PR China.; State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, PR China.
Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, PR China.; State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, PR China..
Life Sci. 2024 Oct 15;355:123000. doi: 10.1016/j.lfs.2024.123000. Epub 2024 Aug 20.
Lung ischemia-reperfusion injury (LIRI) poses a significant challenge in various clinical scenarios. Despite extensive research on the pathogenesis and potential treatments of LIRI, there is a notable absence of bibliometric analysis.
We summarized the results of LIRI research through two searches on the Web of Science, covering data from 1979 to 2023 with topic words "lung" and "reperfusion injury". The collected data were analyzed and visualized based on country, author(s), and keywords by bibliometric software. The keyword "programmed cell death" was further added to explore the hotspot of the LIRI research field.
The initial analysis of 1648 research articles showed a total of 40 countries and 7031 researchers were involved in the publications, with America being the most productive country in the research field of LIRI. Keyword analysis revealed that the evolving focus of LIRI research has progressively transitioned from, lung transplantation, primary graft dysfunction, inflammation, oxidative stress, and ex vivo lung perfusion to cell death. Subsequently, 212 publications specifically addressing programmed cell death (PCD) in LIRI were identified, which clarified the recent hotspot of the LIRI field.
With closer international cooperation and increasing research scale, the LIRI research focused mainly on the pathogenesis and potential therapeutic interventions for LIRI. PCD in LIRI is becoming a trending topic and will continue to be a hotspot in this field. Our study may offer valuable guidance for future research endeavors concerning LIRI.
肺缺血再灌注损伤（LIRI）在各种临床情况下都构成了重大挑战。尽管对 LIRI 的发病机制和潜在治疗方法进行了广泛的研究，但缺乏文献计量学分析。
我们通过在 Web of Science 上进行两次搜索，总结了 LIRI 研究的结果，涵盖了 1979 年至 2023 年的数据，主题词为“lung”和“reperfusion injury”。使用文献计量学软件对收集的数据进行了基于国家、作者和关键词的分析和可视化。进一步添加了关键词“程序性细胞死亡”，以探讨 LIRI 研究领域的热点。
对 1648 篇研究文章的初步分析显示，共有 40 个国家和 7031 名研究人员参与了该领域的发表，美国是 LIRI 研究领域最具生产力的国家。关键词分析显示，LIRI 研究的重点逐渐从肺移植、原发性移植物功能障碍、炎症、氧化应激和离体肺灌注转移到细胞死亡。随后，确定了 212 篇专门探讨 LIRI 中程序性细胞死亡（PCD）的出版物，阐明了 LIRI 领域的近期热点。
随着国际合作的加强和研究规模的扩大，LIRI 的研究重点主要集中在 LIRI 的发病机制和潜在治疗干预措施上。LIRI 中的 PCD 正在成为一个热门话题，并将继续成为该领域的热点。我们的研究可能为未来关于 LIRI 的研究工作提供有价值的指导。
