Gemmell H G, Smith F W, Innes A, Edward N, Catto G R
Department of Bio-Medical Physics and Bio-Engineering, University of Aberdeen, Scotland.
Nucl Med Commun. 1985 Feb;6(2):67-74.
The value of 99Tcm-DPTA transit times and NMR T1 measurements in monitoring the progress of renal transplants has been investigated. Renal transit times were calculated from 182 renograms performed on 29 patients and from 22 of these patients 67 proton spin-lattice relaxation time (T1) measurements were obtained using the Aberdeen Mk 2 NMR Imager. The clinical status of each patient at the time of investigation was defined in retrospect. The principal value of the mean transit time (MTT) was in differentiating between acute rejection and other causes of raised plasma creatinine. During a rejection episode the MTT is raised out of the normal range of 227 +/- 26 s but with chronic rejection or other causes of raised plasma creatinine the MTT remains within normal limits. NMR T1 values appeared to be of little diagnostic value as the normal range was found to be very wide ranging from 340 to 640 ms.
已对99锝-二乙三胺五醋酸（99Tcm-DPTA）通过时间和核磁共振（NMR）T1测量值在监测肾移植进展中的价值进行了研究。肾通过时间是根据对29例患者进行的182次肾图计算得出的，并且从这些患者中的22例使用阿伯丁Mk 2 NMR成像仪获得了67次质子自旋-晶格弛豫时间（T1）测量值。回顾性地确定了每位患者在调查时的临床状态。平均通过时间（MTT）的主要价值在于区分急性排斥反应与血浆肌酐升高的其他原因。在排斥反应发作期间，MTT升高超出了227±26秒的正常范围，但在慢性排斥反应或血浆肌酐升高的其他原因情况下，MTT仍保持在正常范围内。NMR T1值似乎几乎没有诊断价值，因为发现正常范围非常宽，从340到640毫秒不等。
