Wen Jiaxing, Aihemaitijiang Sumiya, Li Hongtian, Zhou Yubo, Liu Jianmeng
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China.
Nutr Metab Cardiovasc Dis. 2025 Feb;35(2):103699. doi: 10.1016/j.numecd.2024.07.016. Epub 2024 Jul 25.
Evidence on the association of maternal obesity with offspring cardiometabolic health is limited, particularly for the Asian population. We aimed to examine the associations of maternal body mass index (BMI) in early pregnancy and gestational weight gain (GWG) rate in mid- and late-pregnancy with childhood cardiometabolic traits.
We used data of 1452 mother-child pairs from a population-based prospective cohort study in China. Maternal BMI in early pregnancy and GWG rate in mid- and late-pregnancy were calculated. Childhood cardiometabolic traits were assessed at aged 4-7 years, including BMI, BMI-z, systolic blood pressure (SBP), diastolic blood pressure, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglycerides, fasting glucose, and C-reactive protein. Each 1 kg/m increase in maternal BMI in early pregnancy was associated with 0.46% (95% confidence interval, 0.19%-0.72%) higher children BMI, 0.05 (0.02-0.08) higher BMI-z, 0.41% (0.22%-0.59%) higher waist circumference, and 0.24% (0.03%-0.46%) higher SBP. Each 1 kg/week higher GWG rate in mid- and late-pregnancy was associated with higher children SBP (4.58% [1.46%-7.71%]), triglycerides (18.28% [3.13%-33.44%]), and fasting glucose (5.83% [2.64%-9.02%]) and lower BMI-z (-0.45 [-0.82 to -0.08]). Additional adjustment for offspring BMI attenuated the associations for maternal BMI but not for GWG rate.
The increase in maternal BMI and GWG are associated with adverse cardiometabolic profiles in childhood. The association between maternal BMI and childhood cardiometabolic traits is likely mediated using the offspring BMI.
关于母亲肥胖与后代心脏代谢健康之间关联的证据有限，尤其是在亚洲人群中。我们旨在研究孕早期母亲体重指数（BMI）以及孕中期和晚期的孕期体重增加（GWG）率与儿童心脏代谢特征之间的关联。
我们使用了来自中国一项基于人群的前瞻性队列研究的1452对母婴数据。计算了孕早期母亲BMI以及孕中期和晚期的GWG率。在儿童4至7岁时评估其心脏代谢特征，包括BMI、BMI-z、收缩压（SBP）、舒张压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、空腹血糖和C反应蛋白。孕早期母亲BMI每增加1kg/m²，儿童BMI升高0.46%（95%置信区间，0.19%-0.72%），BMI-z升高0.05（0.02-0.08），腰围增加0.41%（0.22%-0.59%），SBP升高0.24%（0.03%-0.46%）。孕中期和晚期GWG率每增加1kg/周，儿童SBP升高（4.58%[1.46%-7.71%]）、甘油三酯升高（18.28%[3.13%-33.44%]）、空腹血糖升高（5.83%[2.64%-9.02%]），而BMI-z降低（-0.45[-0.82至-0.08]）。对后代BMI进行额外调整后，减弱了母亲BMI的关联，但未减弱GWG率的关联。
母亲BMI和GWG的增加与儿童不良心脏代谢状况相关。母亲BMI与儿童心脏代谢特征之间的关联可能通过后代BMI介导。
