Provencio Jose Javier, Inkelas Sonya, Vergouwen Mervyn D I
Department of Neurology, University of Virginia, Charlottesville, VA, USA.
Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Transl Stroke Res. 2025 Feb;16(1):18-24. doi: 10.1007/s12975-024-01290-5. Epub 2024 Aug 21.
Specific inflammatory pathways are important in the development of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Understanding the specific pathways of inflammation may be critical for finding new treatments. Evidence is accumulating that innate inflammatory cells and proteins play a more important role than cells of the adaptive inflammatory system. In this work, we review the evidence from clinical and preclinical data regarding which cells of the immune system play a role in DCI with particular emphasis on the bone-marrow-derived cells monocytes and neutrophils and the brain parenchymal microglia. In addition, we will review the evidence that complement proteins, a non-cellular part of the innate immune system, play a role in the development of DCI.
特定的炎症通路在动脉瘤性蛛网膜下腔出血后迟发性脑缺血的发生发展中起重要作用。了解炎症的具体通路对于寻找新的治疗方法可能至关重要。越来越多的证据表明，先天性炎症细胞和蛋白质比适应性炎症系统的细胞发挥更重要的作用。在这项工作中，我们回顾了来自临床和临床前数据的证据，这些证据表明免疫系统的哪些细胞在迟发性脑缺血中起作用，特别强调骨髓来源的细胞单核细胞和中性粒细胞以及脑实质小胶质细胞。此外，我们将回顾补体蛋白（先天性免疫系统的非细胞部分）在迟发性脑缺血发生发展中起作用的证据。
