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使用多功能成分和其他化妆品成分制备具有自我保存功能的个人护理化妆品。

Preparation of self-preserving personal care cosmetic products using multifunctional ingredients and other cosmetic ingredients.

机构信息

Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, 600 117, India.

Department of Biotechnology, School of Life Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, 600 117, India.

出版信息

Sci Rep. 2024 Aug 21;14(1):19401. doi: 10.1038/s41598-024-57782-9.

Abstract

The development of self-preserving personal care cosmetics represents a significant advancement in the cosmetics industry, offering safer and more natural alternatives to consumers. This study focused on the preparation of such formulations using multifunctional ingredients along with other cosmetic components. Five unique multifunctional ingredients (MFIs) were identified based on their antimicrobial properties: sodium coco PG-dimonium chloride phosphate, ricinoleic acid, palmitoleic acid, raspberry ketone, and sorbitan caprylate. Through meticulous experimentation, 150 combinations of MFIs were prepared and tested to understand their synergistic actions. From these trials, three synergistic antimicrobial compositions were determined: sodium coco PG-dimonium chloride phosphate: ricinoleic acid: raspberry ketone in the ratios 1:6.3:6.3 and 1:6.3:15.7. Sodium coco PG-dimonium chloride phosphate: palmitoleic acid: sorbitan caprylate at a ratio of 1:12.5:37.5. These synergistic compositions exhibited enhanced antimicrobial efficacy compared with their individual components, as evidenced by their lower Minimum Inhibitory Concentration values. Incorporating these formulations into three distinct personal care cosmetic products, including a color protection shampoo, body wash shower gel, and skin-lightening cream, the study further validated their effectiveness. A Preservation Challenge Test study revealed that all three antimicrobial compositions successfully preserved the cosmetic formulations for up to 28 days. This method of product preservation not only ensures consumer safety and stability but also reduces the need for potentially conventional preservatives. In conclusion, the appropriate use of multifunctional ingredients in combination with meticulous formulation techniques has led to the successful development of self-preserving personal care cosmetics. These formulations offer a promising avenue for the cosmetic industry, catering to the rising demand for natural, effective, and consumer-friendly cosmetic products.

摘要

具有防腐功能的个人护理化妆品的开发代表了化妆品行业的重大进步,为消费者提供了更安全、更天然的替代品。本研究专注于使用多功能成分以及其他化妆品成分来制备此类配方。根据其抗菌性能,确定了五种独特的多功能成分 (MFI):椰油基 PG-二甲基氯化铵磷酸酯、蓖麻醇酸、棕榈油酸、覆盆子酮和山梨坦辛酸酯。通过精心的实验,制备并测试了 150 种 MFI 组合,以了解它们的协同作用。从这些试验中,确定了三种协同抗菌组合物:椰油基 PG-二甲基氯化铵磷酸酯:蓖麻醇酸:覆盆子酮的比例为 1:6.3:6.3 和 1:6.3:15.7。椰油基 PG-二甲基氯化铵磷酸酯:棕榈油酸:山梨坦辛酸酯的比例为 1:12.5:37.5。这些协同组合物表现出比其单个成分更高的抗菌功效,这一点从它们更低的最低抑菌浓度值可以证明。将这些配方纳入三种不同的个人护理化妆品中,包括彩色保护洗发水、沐浴露沐浴凝胶和皮肤美白霜,进一步验证了它们的功效。防腐剂挑战测试研究表明,所有三种抗菌组合物都成功地将化妆品配方保存了长达 28 天。这种产品保存方法不仅确保了消费者的安全和稳定性,而且减少了对传统防腐剂的需求。总之,适当使用多功能成分并结合精心的配方技术,成功开发了具有防腐功能的个人护理化妆品。这些配方为化妆品行业提供了一个有前途的途径,迎合了对天然、有效和消费者友好的化妆品产品的日益增长的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fab9/11339294/9be58f58751d/41598_2024_57782_Fig1_HTML.jpg

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