Harvard Neonatal-Perinatal Medicine Fellowship Program, Boston, Massachusetts.
Division of Newborn Medicine, Department of Pediatrics.
Pediatrics. 2024 Sep 1;154(3). doi: 10.1542/peds.2023-065117.
Neonatal hypothermia is a common and preventable cause of neonatal morbidity and mortality. Although hypothermia prevention has been extensively studied in infants <32 weeks' gestation, the authors of few studies have targeted moderate- and late-preterm infants (MLPIs) in the delivery room.
This quality improvement initiative was conducted from June 2019 to June 2023 at the Massachusetts General Hospital NICU and Labor and Delivery Unit. All inborn MLPIs 32 + 0/7 to 36 + 6/7 weeks' gestation admitted to the NICU were included. We expanded thermoregulatory measures typically used in protocols for infants <32 weeks' gestation, including increasing delivery room ambient temperature to 74°F and thermal mattress use. The primary outcome was hypothermia (<36.5°C) after NICU admission. The balancing measure was hyperthermia (≥38 °C).
During the study period, there were 566 inborn MLPIs with a mean gestational age of 34 + 3/7 weeks and a mean birth weight of 2269 g. Special cause variation in neonatal hypothermia incidence was observed with a decrease from a mean baseline of 27% to 7.8% postintervention. Special cause variation was observed in hyperthermia incidence, with an increase from 1.4% to 6.2% postintervention largely initially associated with noncompliance with the protocol for thermal mattress removal.
The expansion of several thermoregulation techniques commonly used in infants <32 weeks' gestation, particularly thermal mattress use, was associated with a decreased incidence of NICU admission hypothermia in MLPIs, with an increase in mild hyperthermia predominantly associated with concomitant polyethylene wrap use.
新生儿低体温是新生儿发病率和死亡率的常见且可预防的原因。尽管在<32 周龄的婴儿中广泛研究了预防低体温,但很少有研究针对产房中的中-晚期早产儿(MLPI)。
这项质量改进倡议于 2019 年 6 月至 2023 年 6 月在马萨诸塞州总医院新生儿重症监护病房(NICU)和分娩病房进行。所有入组的 32+0/7 至 36+6/7 周龄的固有 MLPI 均包括在内。我们扩大了通常在<32 周龄婴儿方案中使用的体温调节措施,包括增加产房环境温度至 74°F 和使用热床垫。主要结局是 NICU 入院后低体温(<36.5°C)。平衡措施是体温过高(≥38°C)。
在研究期间,有 566 例固有 MLPI,平均胎龄为 34+3/7 周,平均出生体重为 2269g。新生儿低体温发生率存在特殊原因变化,从干预前的平均基线 27%降至 7.8%。体温过高的发生率也存在特殊原因变化,从干预前的 1.4%增加到 6.2%,主要与最初不遵守热床垫去除方案有关。
扩大几种在<32 周龄婴儿中常用的体温调节技术,特别是使用热床垫,与 MLPI 中 NICU 入院低体温发生率降低有关,轻度体温过高增加主要与同时使用聚乙烯包装有关。