Zhou Wensheng, Zhao Lishu, Wang Hao, Liu Xinyue, Liu Yujin, Xu Kandi, Yu Hui, Suda Kenichi, He Yayi
Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China.
Chin Med J Pulm Crit Care Med. 2023 Apr 18;1(2):94-101. doi: 10.1016/j.pccm.2023.03.001. eCollection 2023 Jun.
Pyroptosis is a type of programed cell death that differs from apoptosis, ferroptosis, or necrosis. Numerous studies have reported that it plays a critical role in tumorigenesis and modification of the tumor microenvironment in multiple tumors. In this review, we briefly describe the canonical, non-canonical, and alternative mechanisms of pyroptotic cell death. We also summarize the potential roles of pyroptosis in oncogenesis, tumor development, and lung cancer treatment, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Pyroptosis has double-edged effects on the modulation of the tumor environment and lung cancer treatment. Further exploration of pyroptosis-based drugs could provide novel therapeutic strategies for lung cancer.
细胞焦亡是一种程序性细胞死亡，不同于凋亡、铁死亡或坏死。大量研究表明，它在多种肿瘤的肿瘤发生和肿瘤微环境改变中起关键作用。在本综述中，我们简要描述了细胞焦亡性细胞死亡的经典、非经典和替代机制。我们还总结了细胞焦亡在肿瘤发生、肿瘤发展和肺癌治疗（包括化疗、放疗、靶向治疗和免疫治疗）中的潜在作用。细胞焦亡在肿瘤环境调节和肺癌治疗中具有双刃剑效应。进一步探索基于细胞焦亡的药物可为肺癌提供新的治疗策略。
