处方复杂性：一个与癫痫病史及阿尔茨海默病不断变化的治疗格局相关的患者故事。
Prescribing Complexities: A Patient Story Related to Seizure History and the Changing Therapeutic Landscape of Alzheimer's Disease.
作者信息
Umoh Mfon E, Terman Samuel W
机构信息
Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Neurology, University of Michigan, Ann Arbor, USA.
出版信息
Cureus. 2024 Jul 22;16(7):e65127. doi: 10.7759/cureus.65127. eCollection 2024 Jul.
The therapeutic landscape of Alzheimer's disease (AD) is rapidly changing. Disease-modifying medications for AD that target amyloid-beta (Aß) deposits in the brain have been approved by the Food and Drug Administration (FDA) in recent years. However, there remain many questions about which patients are most appropriate for these medications. One group in particular with unique considerations includes older adults with a prior history of seizures. AD and seizures represent an important, bidirectional relationship. This case report presents a patient story that highlights the importance of discussions around seizure history in consideration of anti-amyloid medications and the importance of risk-benefit assessments when considering anti-amyloid therapeutics for patients with AD.
阿尔茨海默病（AD）的治疗格局正在迅速变化。近年来，针对大脑中β-淀粉样蛋白（Aβ）沉积的AD疾病修饰药物已获美国食品药品监督管理局（FDA）批准。然而，对于哪些患者最适合使用这些药物仍存在许多问题。特别需要特殊考虑的一类人群包括有癫痫发作史的老年人。AD与癫痫发作呈现出一种重要的双向关系。本病例报告讲述了一个患者的故事，突出了在考虑使用抗淀粉样蛋白药物时围绕癫痫发作史进行讨论的重要性，以及在为AD患者考虑抗淀粉样蛋白治疗时进行风险效益评估的重要性。
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