健康对照者运动性言语功能神经影像学的特征及可重复性。
The characteristics and reproducibility of motor speech functional neuroimaging in healthy controls.
作者信息
Kenyon Katherine H, Boonstra Frederique, Noffs Gustavo, Morgan Angela T, Vogel Adam P, Kolbe Scott, Van Der Walt Anneke
机构信息
Department of Neuroscience, School of Translational Medicine, Melbourne, VIC, Australia.
Redenlab Inc., Melbourne, VIC, Australia.
出版信息
Front Hum Neurosci. 2024 Aug 7;18:1382102. doi: 10.3389/fnhum.2024.1382102. eCollection 2024.
INTRODUCTION
Functional magnetic resonance imaging (fMRI) can improve our understanding of neural processes subserving motor speech function. Yet its reproducibility remains unclear. This study aimed to evaluate the reproducibility of fMRI using a word repetition task across two time points.
METHODS
Imaging data from 14 healthy controls were analysed using a multi-level general linear model.
RESULTS
Significant activation was observed during the task in the right hemispheric cerebellar lobules IV-V, right putamen, and bilateral sensorimotor cortices. Activation between timepoints was found to be moderately reproducible across time in the cerebellum but not in other brain regions.
DISCUSSION
Preliminary findings highlight the involvement of the cerebellum and connected cerebral regions during a motor speech task. More work is needed to determine the degree of reproducibility of speech fMRI before this could be used as a reliable marker of changes in brain activity.
引言
功能磁共振成像（fMRI）能够增进我们对支持运动性言语功能的神经过程的理解。然而，其可重复性仍不明确。本研究旨在评估使用单词重复任务在两个时间点进行fMRI的可重复性。
方法
使用多级一般线性模型分析了14名健康对照者的成像数据。
结果
在任务期间，右侧半球小脑小叶IV - V、右侧壳核以及双侧感觉运动皮层观察到显著激活。发现时间点之间的激活在小脑中随时间具有中度可重复性，但在其他脑区则不然。
讨论
初步研究结果突出了小脑和相连脑区在运动性言语任务中的参与。在将言语fMRI用作脑活动变化的可靠标志物之前，需要开展更多工作来确定其可重复性程度。
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