Wadhwani Nikhar, Bhola Nitin
Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra (442001), India.
J Surg Case Rep. 2024 Aug 21;2024(8):rjae484. doi: 10.1093/jscr/rjae484. eCollection 2024 Aug.
An uncommon entity in the class of malignant neuroectodermal nasal tumors is the olfactory neuroblastoma, which originates in the roof of the nasal cavity from the olfactory epithelium. It is often mistaken by clinicians for a nasal polyp because it presents with indistinct features such as nasal obstruction and secondary sinus disease. Olfactory neuroblastoma has been observed to cause morbidity by distant metastasis, invasion through the cribriform plate, and secondary meningitis in most instances. It exhibits a range of biologic activities, from slow growth accompanied by long-term patient survival to a very aggressive malignancy with extensive metastases. We report the incidence of a rare case in which a patient, previously operated on and irradiated for squamous cell carcinoma of the maxilla, developed an olfactory neuroblastoma with orbital protrusion.
嗅神经母细胞瘤是恶性神经外胚层鼻腔肿瘤中的一种罕见实体，它起源于鼻腔顶部的嗅上皮。临床医生常将其误诊为鼻息肉，因为它表现出如鼻塞和继发性鼻窦疾病等不明确的特征。在大多数情况下，嗅神经母细胞瘤已被观察到可通过远处转移、穿过筛板侵犯以及继发性脑膜炎导致发病。它表现出一系列生物学行为，从生长缓慢且患者长期存活到具有广泛转移的极具侵袭性的恶性肿瘤。我们报告了一例罕见病例的发生率，该患者曾因上颌鳞状细胞癌接受手术和放疗，之后发生了伴有眼眶突出的嗅神经母细胞瘤。
