Heterochiral π-Stacking Dimerization of Helical Secondary Structures with Emerging Supramolecular Chirality.
作者信息
Li Wencan, Shao Yiqi, Xu Zhaocheng, Ge Yunpeng, Wang Zhenzhu, Jiang Hua, Dong Zeyuan
机构信息
State Key Laboratory of Supramolecular Structure and Materials, and Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
College of Chemistry, Beijing Normal University, Beijing, 100875, China.
出版信息
Angew Chem Int Ed Engl. 2025 Jan 10;64(2):e202414317. doi: 10.1002/anie.202414317. Epub 2024 Oct 17.
A specific interface mode type was observed between helical secondary structures, in which a left-handed (M) helix binds specifically to a right-handed (P) helix along the helical axis, leading to the formation of discrete heterochiral helical dimers. Moreover, a concealed supramolecular chirality within the meso-supramolecular dimers was unexpectedly discovered by chiral induction, and was further underpinned by covalent meso-helix structures.
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