Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University.
Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.
J Craniofac Surg. 2024 Oct 1;35(7):e670-e672. doi: 10.1097/SCS.0000000000010537. Epub 2024 Aug 22.
Olfactory neuroblastoma (ONB) is an uncommon malignant tumor typically located in the upper nasal cavity. Olfactory neuroblastoma originating in the nasopharynx is extremely rare and tends to be misdiagnosed. The authors describe a rare case of ONB arising ectopically in the nasopharynx. The patient was a 65-year-old woman with recurrent epistaxis and a feeling of fullness in the right ear. After evaluation, endoscopic surgery was performed. The pathological result proved to be ONB. Postoperative magnetic resonance imaging showed that the tumor was completely resected. The patient proceeded to have 66 Gy of postoperative intensity-modulated radiotherapy and was followed for 36 months without tumor recurrence. Olfactory neuroblastoma originating from the nasopharynx is more rare condition compared with ONB located in other areas in the literature. The symptoms of ONB ectopic to the nasopharynx are similar to those of other nasopharyngeal tumors, which were likely to be misdiagnosed. The treatment principle is the same as that of nonectopic ONB, which is surgery combined with radiotherapy. Surgery can be performed using an endoscopic transnasal approach.
嗅神经母细胞瘤（ONB）是一种罕见的恶性肿瘤，通常位于鼻腔上部。起源于鼻咽部的嗅神经母细胞瘤极为罕见，且易于误诊。作者描述了一例罕见的发生于鼻咽部的嗅神经母细胞瘤异位病例。患者为 65 岁女性，反复鼻出血，右耳有饱满感。经评估后，行内镜手术。病理结果证实为嗅神经母细胞瘤。术后磁共振成像显示肿瘤完全切除。患者随后接受了 66Gy 的术后强度调制放疗，并随访 36 个月，未见肿瘤复发。与文献中其他部位的 ONB 相比，起源于鼻咽部的嗅神经母细胞瘤更为罕见。发生于鼻咽部的嗅神经母细胞瘤的症状与其他鼻咽部肿瘤相似，容易误诊。治疗原则与非异位 ONB 相同，即手术联合放疗。手术可经内镜经鼻入路进行。
