Morgan Mirette A, Saleh Sarra E, Salamoni Azza H, Alshahrani Mohammad Y, Aboshanab Khaled M
External Quality Assurance Laboratory, Central Public Health of Laboratories CPHL, Ministry of Health, Cairo, 11613, Egypt.
Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 1566, Egypt.
Future Sci OA. 2024 Dec 31;10(1):2389664. doi: 10.1080/20565623.2024.2389664. Epub 2024 Aug 22.
To correlate hematological, inflammatory indicators and serological responses among COVID-19 patients to point out the significant biomarkers for disease management and prognosis. Standard analytical and molecular methods were used to assess various inflammatory and serological Responses among COVID-19 patients (ICU- (n = 99) and non-ICU patients (n = 64) as compared with health control (n = 40). Significant differences in the Hb, WBC, Lymphocyte count, CRP and serum ferritin ( < 0.05) were observed. Patients' IgM/IgG antibodies against SARS-CoV-2 were associated with increased CRP, LDH and serum ferritin levels. A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission.
关联新冠肺炎患者的血液学、炎症指标和血清学反应,以指出疾病管理和预后的重要生物标志物。采用标准分析和分子方法评估新冠肺炎患者(99例重症监护病房患者和64例非重症监护病房患者)与健康对照者(40例)的各种炎症和血清学反应。观察到血红蛋白、白细胞、淋巴细胞计数、C反应蛋白和血清铁蛋白存在显著差异(P<0.05)。患者针对严重急性呼吸综合征冠状病毒2的IgM/IgG抗体与C反应蛋白、乳酸脱氢酶和血清铁蛋白水平升高相关。观察到血清IgG/IgM与入住重症监护病房之间存在显著关联。尽管血清铁蛋白和乳酸脱氢酶可以提供有关炎症程度的信息,但它们并非入住重症监护病房的唯一因素。