血小板与白细胞比值作为重症新型冠状病毒肺炎患者死亡率的预测指标：一项回顾性队列研究
Platelet-to-White Blood Cell Ratio as a Predictor of Mortality in Patients with Severe COVID-19 Pneumonia: A Retrospective Cohort Study.
作者信息
Thungthienthong Metus, Vattanavanit Veerapong
机构信息
Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Critical Care Medicine Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
出版信息
Infect Drug Resist. 2023 Jan 24;16:445-455. doi: 10.2147/IDR.S398731. eCollection 2023.
PURPOSE
Complete blood count (CBC) parameters are widely used as predictors of Coronavirus disease 2019 (COVID-19) severity. However, the clinical significance of these markers in severe COVID-19 pneumonia remains unclear. This study aimed to investigate the role of CBC parameters in predicting mortality in patients with severe COVID-19 pneumonia.
PATIENTS AND METHODS
We conducted a retrospective study at a tertiary care center in southern Thailand. Between January 2020 and December 2021, adult patients who had been diagnosed with severe COVID-19 pneumonia were enrolled. Demographic and clinical data, including CBC data on admission, were analyzed and compared between survivors and non-survivors.
RESULTS
A total of 215 patients with severe COVID-19 pneumonia were enrolled. The in-hospital mortality was 29.3%. Non-survivors had a significantly lower platelet-to-white blood cell ratio (PWR) than survivors (15.8 vs 29.0, p < 0.001). PWR had the best accuracy in predicting in-hospital mortality, with an area under the curve (AUC) of the receiver operating characteristic curve of 0.801, followed by the CURB-65 of 0.789.
CONCLUSION
PWR appears to be a simple independent predictor of mortality in patients with severe COVID-19 pneumonia.
目的
全血细胞计数（CBC）参数被广泛用作2019冠状病毒病（COVID-19）严重程度的预测指标。然而，这些标志物在重症COVID-19肺炎中的临床意义仍不明确。本研究旨在探讨CBC参数在预测重症COVID-19肺炎患者死亡率中的作用。
患者与方法
我们在泰国南部的一家三级医疗中心进行了一项回顾性研究。2020年1月至2021年12月期间，纳入被诊断为重症COVID-19肺炎的成年患者。分析并比较了幸存者和非幸存者的人口统计学和临床数据，包括入院时的CBC数据。
结果
共纳入215例重症COVID-19肺炎患者。住院死亡率为29.3%。非幸存者的血小板与白细胞比值（PWR）显著低于幸存者（15.8对29.0，p<0.001）。PWR在预测住院死亡率方面具有最佳准确性，受试者工作特征曲线下面积（AUC）为0.801，其次是CURB-65，为0.789。
结论
PWR似乎是重症COVID-19肺炎患者死亡率的一个简单独立预测指标。
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