Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
Curr Opin Struct Biol. 2024 Oct;88:102897. doi: 10.1016/j.sbi.2024.102897. Epub 2024 Aug 21.
The membrane proximal external region (MPER) of the HIV envelope glycoproteins has generated renewed interest after a recent phase I vaccine trial that presented MPER lipid-peptide epitopes demonstrated promise to elicit a broad neutralization response. The antigenicity of MPER is intimately associated with the membrane, and its presentation relies significantly on the lipid composition. This review brings together recent findings on the influence of membranes on the conformation of MPER and its recognition by broadly neutralizing antibodies. Specifically, the review highlights the importance of properly accounting for the balance between protein-protein and membrane-protein interactions in vaccine design.
HIV 包膜糖蛋白的膜近端外部区域 (MPER) 在最近的一项 I 期疫苗试验后重新引起了人们的兴趣，该试验表明，MPER 脂质肽表位有希望引发广泛的中和反应。MPER 的抗原性与膜密切相关，其呈现很大程度上依赖于脂质组成。这篇综述汇集了最近关于膜对 MPER 构象及其与广泛中和抗体识别的影响的发现。具体来说，该综述强调了在疫苗设计中正确考虑蛋白质-蛋白质和膜蛋白相互作用之间平衡的重要性。
