Emerg Infect Dis. 2024 Sep;30(9):1747-1754. doi: 10.3201/eid3009.240150.
Measles in persons with secondary vaccination failure (SVF) may be less infectious than cases in unvaccinated persons. Our systematic review aimed to assess transmission risk for measles after SVF. We searched PubMed, Embase, and Web of Science databases from their inception dates. Inclusion criteria were articles describing persons who were exposed to measles-infected persons who had experienced SVF. Across the included 14 studies, >3,030 persons were exposed to measles virus from SVF cases, of whom 180 were susceptible, indicating secondary attack rates of 0%-6.25%. We identified 109 cases of SVF from the studies; 10.09% (n = 11) of case-patients transmitted the virus, resulting in 23 further cases and yielding an effective reproduction number of 0.063 (95% CI 0.0-0.5). These findings suggest a remarkably low attack rate for SVF measles cases, suggesting that, In outbreak situations, public health management of unvaccinated persons could be prioritized over persons with SVF.
二次疫苗失效（SVF）人群发生的麻疹病例可能不如未接种人群中的麻疹病例具有传染性。我们的系统评价旨在评估 SVF 后麻疹的传播风险。我们检索了 PubMed、Embase 和 Web of Science 数据库的起始日期。纳入标准是描述接触过经历 SVF 的麻疹感染者的人群的文章。在纳入的 14 项研究中，超过 3030 人接触过 SVF 病例中的麻疹病毒，其中 180 人为易感者，表明二次攻击率为 0%-6.25%。我们从研究中确定了 109 例 SVF；10.09%（n=11）的病例患者传播了病毒，导致 23 例进一步的病例，有效繁殖数为 0.063（95%CI 0.0-0.5）。这些发现表明 SVF 麻疹病例的攻击率非常低，这表明在暴发情况下，对未接种人群的公共卫生管理可以优先于 SVF 人群。
