Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function And Cognitive Magnetic Resonance Imaging, China.
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function And Cognitive Magnetic Resonance Imaging, China.
Brain Res Bull. 2024 Oct 1;216:111052. doi: 10.1016/j.brainresbull.2024.111052. Epub 2024 Aug 20.
Internet gaming disorder (IGD) is mainly characterized by its core dysfunction in higher-order brain cortices involved in inhibitory control, whose neurobiological basis remains unclear. Then, we will investigate local intrinsic neural activity (INA) alterations in IGD, ascertain whether these potential alterations are related to clinical characteristics, and further explore the underlying molecular architecture.
In this study, we performed the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) derived from resting-state functional magnetic resonance imaging (rs-fMRI) to explore the impact of IGD on local INA. Correlation analysis revealed the relationship between ReHo and fALFF in terms of group differences and clinical characteristics. Moreover, correlations between fALFF, ReHo, and PET- and SPECT-driven maps were investigated to elucidate the specific molecular architecture alternations in IGD. Finally, receiver operating characteristic curve (ROC) analysis was used to show the potential abilities of fALFF and ReHo in distinguishing individuals with IGD (IGDs) from healthy controls (HCs).
Compared with HCs, IGDs revealed increased ReHo and fALFF in the prefrontal cortex. Significantly decreased ReHo was observed in the temporal lobe, occipital lobe, and cerebellum. In addition, the ReHo values in the cerebellum_7b_R were positively correlated with internet addiction severity. ROC curve analysis showed that ReHo and fALFF-altered brain regions could effectively distinguish IGDs from HCs. More importantly, cross-modal correlations revealed local INA changes in brain regions associated with the monoamine neurotransmitter system and the less studied cholinergic/GABAergic system.
These results suggest that local functional impairments are shown in the audiovisual and inhibitory control circuits in IGDs. This may be associated with underlying neurotransmitter system alterations. Therefore, this study provides the possibility of GABAergic receptor agonists and cholinergic receptor inhibitors for the treatment of IGD.
网络成瘾障碍（IGD）主要表现为涉及抑制控制的高级大脑皮层的核心功能障碍，其神经生物学基础尚不清楚。然后，我们将研究 IGD 中的局部内在神经活动（INA）改变，确定这些潜在的改变是否与临床特征有关，并进一步探索潜在的分子结构。
在这项研究中，我们使用静息态功能磁共振成像（rs-fMRI）的分数低频波动（fALFF）和局部一致性（ReHo）来探索 IGD 对局部 INA 的影响。相关性分析揭示了组间差异和临床特征方面的 ReHo 和 fALFF 之间的关系。此外，还研究了 fALFF、ReHo 与 PET 和 SPECT 驱动图谱之间的相关性，以阐明 IGD 中的特定分子结构改变。最后，使用接收者操作特征曲线（ROC）分析显示 fALFF 和 ReHo 在区分 IGD 个体（IGDs）和健康对照（HCs）方面的潜在能力。
与 HCs 相比，IGDs 在前额叶皮层中显示出增加的 ReHo 和 fALFF。在颞叶、枕叶和小脑中观察到明显降低的 ReHo。此外，小脑_7b_R 的 ReHo 值与网络成瘾严重程度呈正相关。ROC 曲线分析表明，ReHo 和 fALFF 改变的脑区可以有效地将 IGD 与 HCs 区分开来。更重要的是，跨模态相关性揭示了与单胺神经递质系统和研究较少的胆碱能/GABA 能系统相关的大脑区域的局部 INA 变化。
这些结果表明，IGD 中存在视听和抑制控制回路的局部功能障碍。这可能与潜在的神经递质系统改变有关。因此，本研究为 GABA 能受体激动剂和胆碱能受体抑制剂治疗 IGD 提供了可能。
