Ural Federal University, Yekaterinburg, Russia.
Biosystems. 2024 Nov;245:105311. doi: 10.1016/j.biosystems.2024.105311. Epub 2024 Aug 20.
In this study, the complexities of intracellular processes have been analyzed, including DNA folding, alternative splicing, mitochondrial function, and enzyme transport in lysosomes. Based on a previously proposed hypothesis (Levinthal's generalized paradox), a conclusion is made that all abovementioned processes cannot be realized with sufficient accuracy and in a realistic timeframe within the framework of classical physics. It is unclear why the cell functions at all. For the cell to function, its internal environment must be highly structured. In this regard, the cell shares similarities with computational devices (computers). In this study, quantum models of interactions between biologically important molecules were constructed, taking into account the long-range effects. One significant aspect of these models is the special role of the phase of the wavefunction, which serves as a controlling parameter. Experiments have been proposed that may confirm or refute these models.
在这项研究中,分析了包括 DNA 折叠、选择性剪接、线粒体功能和溶酶体中的酶运输在内的细胞内过程的复杂性。基于之前提出的假设(列文塔尔的广义悖论),得出结论,所有上述过程都不能在经典物理学的框架内以足够的准确性和在现实的时间框架内实现。目前还不清楚细胞为什么能够正常运作。为了使细胞发挥功能,其内部环境必须具有高度的结构性。在这方面,细胞与计算设备(计算机)具有相似性。在这项研究中,构建了考虑远程效应的生物重要分子相互作用的量子模型。这些模型的一个重要方面是波函数相位的特殊作用,它作为控制参数。已经提出了一些实验,这些实验可能证实或反驳这些模型。