Wang Yijie, Sun Yue, Tian Yunze, Xie Yunpeng, Li Ting, Zhang Xuhui, Wang Yang, Huang Jing, Xia Bihua, Wang Shibo, Dong Weifu
The Key Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.
The Key Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, Jiangsu, China.
Carbohydr Polym. 2024 Nov 1;343:122498. doi: 10.1016/j.carbpol.2024.122498. Epub 2024 Jul 17.
In recent years, active substances have been extensively applied in the fields of food, cosmetics, and pharmaceuticals. However, their preservation and transportation have posed challenges due to issues such as oxidation and photodegradation. This study proposes a method for synthesizing Zein-Hyaluronic Acid (Zein-HA) conjugate particles via the Schiff base reaction, utilizing these conjugate particles to encapsulate and protect active substances within a stable emulsion system. Compared to zein, the modified conjugate particles exhibit significantly improved dispersibility, amphiphilicity, interfacial affinity, and emulsifying properties. Consequently, these particles are capable of stabilizing high internal phase Pickering emulsions with an oil phase volume fraction of up to 80 (v/v)%, thereby enabling the carriage of a higher load of active components. Furthermore, the prepared emulsions demonstrate excellent storage stability, resistance to ionic strength (250-2000 mM NaCl), and outstanding antioxidative characteristics. Moreover, after 8 h of UV light exposure, the retention rates of the active substances (curcumin, astaxanthin, and resveratrol) exceed 60 %. Therefore, these emulsions hold substantial potential to be applied as a carrier system in the food, cosmetics, and pharmaceutical industries.
近年来，活性物质已广泛应用于食品、化妆品和制药领域。然而，由于氧化和光降解等问题，它们的保存和运输带来了挑战。本研究提出了一种通过席夫碱反应合成玉米醇溶蛋白-透明质酸（Zein-HA）共轭颗粒的方法，利用这些共轭颗粒在稳定的乳液体系中封装和保护活性物质。与玉米醇溶蛋白相比，改性共轭颗粒的分散性、两亲性、界面亲和力和乳化性能显著提高。因此，这些颗粒能够稳定油相体积分数高达80%（v/v）的高内相Pickering乳液，从而能够承载更高负载的活性成分。此外，制备的乳液具有优异的储存稳定性、抗离子强度（250-2000 mM NaCl）和出色的抗氧化特性。此外，在紫外线照射8小时后，活性物质（姜黄素、虾青素和白藜芦醇）的保留率超过60%。因此，这些乳液在食品、化妆品和制药行业作为载体系统具有巨大的应用潜力。
