Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Department of Anatomical Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran.
J Transl Med. 2024 Aug 22;22(1):783. doi: 10.1186/s12967-024-05499-8.
A novel approach to treating heart failures was developed with the introduction of iPSC technology. Knowledge in regenerative medicine, developmental biology, and the identification of illnesses at the cellular level has exploded since the discovery of iPSCs. One of the most frequent causes of mortality associated with cardiovascular disease is the loss of cardiomyocytes (CMs), followed by heart failure. A possible treatment for heart failure involves restoring cardiac function and replacing damaged tissue with healthy, regenerated CMs. Significant strides in stem cell biology during the last ten years have transformed the in vitro study of human illness and enhanced our knowledge of the molecular pathways underlying human disease, regenerative medicine, and drug development. We seek to examine iPSC advancements in disease modeling, drug discovery, iPSC-Based cell treatments, and purification methods in this article.
一种治疗心力衰竭的新方法随着 iPSC 技术的引入而发展。自从 iPSCs 被发现以来，再生医学、发育生物学和细胞水平疾病识别方面的知识已经爆炸式增长。与心血管疾病相关的最常见死亡原因之一是心肌细胞 (CMs) 的丧失，随后是心力衰竭。心力衰竭的一种可能治疗方法是恢复心脏功能，并使用健康的、再生的 CMs 替代受损组织。过去十年间，干细胞生物学领域取得了重大进展，改变了人类疾病的体外研究，并增强了我们对人类疾病、再生医学和药物开发背后分子途径的了解。我们旨在本文中探讨 iPSC 在疾病建模、药物发现、基于 iPSC 的细胞治疗和纯化方法方面的进展。
