El Salmawy Dina Ahmed, Elhadidy Reem, Shuaib Asmaa, Ashraf Mahmoud Eman, Nada Mona M
Clinical Neurophysiology Unit, Neurology Department, Faculty of Medicine, Cairo University, Giza, Egypt ; and.
Opthalmology Department, Faculty of Medicine, Cairo University, Giza, Egypt .
J Clin Neurophysiol. 2025 May 1;42(4):365-375. doi: 10.1097/WNP.0000000000001110. Epub 2024 Aug 23.
Amblyopia is defined clinically as a difference in best-corrected visual acuity of two or more lines of acuity (0.2 logMAR) between the eyes. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that can transiently alter the excitability of targeted brain areas in a polarity-specific manner.
To detect the effect of tDCS on anisometropic amblyopia.
This is a randomized controlled trial conducted on 78 patients with anisometropic amblyopia from 4.5 to 12 years of age. All patients presented with monocular amblyopia. They were divided into three groups; each group received five sessions of tDCS (anodal tDCS, cathodal tDCS, and sham tDCS). The active electrode was placed over occipital midline and the reference over central midline. Pattern visual-evoked potentials and contrast sensitivity tests were conducted before, immediately after, and 1 week after tDCS.
The amplitude of P100 was significantly decreased immediately after and 1 week after cathodal tDCS. The latency of P100 immediately after and 1 week after anodal tDCS was significantly decreased and increased significantly after cathodal tDCS. The amplitude of P100 and maximum and minimum contrast sensitivities were significantly increased immediately after and 1 week after anodal tDCS, and maximum contrast sensitivity was significantly decreased immediately after cathodal tDCS.
Anodal tDCS is a promising noninvasive modality for improvement of anisometropic amblyopia.
弱视在临床上被定义为双眼最佳矫正视力相差两行或更多行（0.2对数最小分辨角）。经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，能够以极性特异性方式短暂改变目标脑区的兴奋性。
检测经颅直流电刺激对屈光参差性弱视的影响。
这是一项针对78例4.5至12岁屈光参差性弱视患者的随机对照试验。所有患者均为单眼弱视。他们被分为三组；每组接受5次经颅直流电刺激（阳极经颅直流电刺激、阴极经颅直流电刺激和假经颅直流电刺激）。活性电极置于枕部中线，参考电极置于中央中线。在经颅直流电刺激前、刺激后即刻和刺激后1周进行图形视觉诱发电位和对比敏感度测试。
阴极经颅直流电刺激后即刻和1周后P100波幅显著降低。阳极经颅直流电刺激后即刻和1周后P100潜伏期显著缩短，阴极经颅直流电刺激后显著延长。阳极经颅直流电刺激后即刻和1周后P100波幅以及最大和最小对比敏感度显著增加，阴极经颅直流电刺激后即刻最大对比敏感度显著降低。
阳极经颅直流电刺激是一种有前景的改善屈光参差性弱视的非侵入性方法。
