Zakroyshchikova I V, Simaniv T O, Zemlyanaya D O, Timofeeva A A, Zakharova M N
Research Center of Neurology, Moscow, Russia.
Pirogov Russian National Research Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(7. Vyp. 2):43-49. doi: 10.17116/jnevro202412407243.
Planning for pregnancy and possibility of disease modifying treatment (DMTs) is an important question in female patients of reproductive age who suffer from multiple sclerosis (MS). The frequency of refusals to plan pregnancy is 14%. This is due to numerous concerns about the course of pregnancy, its outcomes, as well as the possible effect of DMTs on the fetus and the probability of disease transmission to a child. The article discusses immunological reactions taking place in MS patients during pregnancy, which are protective in its nature. Data for all groups of DMTs regarding pregnancy planning, possible risks of their impact on fertility and teratogenicity is presented.
对于患有多发性硬化症（MS）的育龄女性患者而言，妊娠规划以及疾病修正治疗（DMTs）的可能性是一个重要问题。拒绝妊娠规划的比例为14%。这是由于对妊娠过程、其结果以及DMTs对胎儿的可能影响和疾病传染给孩子的可能性存在诸多担忧。本文讨论了MS患者在妊娠期间发生的具有保护性质的免疫反应。还介绍了所有DMTs组关于妊娠规划、其对生育力的可能风险以及致畸性的数据。
