Copper-promoted -directed C-H amination of 2-arylpyridines with NH-heterocycles.
作者信息
Zeng Yang-Hao, Dong Lin
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Org Biomol Chem. 2024 Sep 18;22(36):7390-7394. doi: 10.1039/d4ob01126k.
Copper-mediated C-N coupling of azaheterocycles with aryl C-H bonds has been realized for the synthesis of N-(hetero)arylated heteroarenes. This method is characterized by high regioselectivity, atom economy and a wide substrate scope of 2-arylazines and azaheterocycles. The corresponding C-N coupling products were shown to undergo further transformation to synthesize more complex molecules.
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