Shibasaki H, Neshige R, Hashiba Y
Neurology. 1985 Jan;35(1):36-41. doi: 10.1212/wnl.35.1.36.
Cortical excitability after myoclonus was investigated by electrically stimulating the median nerve just at the time of, or at intervals after, the onset of myoclonus and by averaging the EEG and EMG, using the myoclonus onset pulse as a trigger (jerk-locked somatosensory evoked potential technique). In a patient with "cortical reflex" myoclonus, cortical excitability was relatively enhanced for 20 msec just after the myoclonus, although it was suppressed throughout the postmyoclonus period. In a patient with Creutzfeldt-Jakob disease, cortical excitability was suppressed between periodic myoclonic jerks. In a patient with oculopalatal-somatic myoclonus, there was no change of cortical excitability in relation to myoclonus.
通过在肌阵挛发作时或发作后的不同时间间隔电刺激正中神经，并以肌阵挛发作脉冲作为触发信号（抽动锁定体感诱发电位技术），对脑电图（EEG）和肌电图（EMG）进行平均，来研究肌阵挛后的皮质兴奋性。在一名患有“皮质反射性”肌阵挛的患者中，尽管在肌阵挛后整个时期皮质兴奋性受到抑制，但在肌阵挛刚结束后的20毫秒内，皮质兴奋性相对增强。在一名患有克雅氏病的患者中，周期性肌阵挛抽搐之间皮质兴奋性受到抑制。在一名患有眼腭体肌阵挛的患者中，皮质兴奋性与肌阵挛无关，没有变化。
