Sasaki Makoto, Hirata Rieko, Konagai Ayano, Ebara Mitsuhiro
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS) 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan
Graduate School of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8577 Japan.
RSC Adv. 2024 Aug 22;14(36):26596-26603. doi: 10.1039/d4ra04501g. eCollection 2024 Aug 16.
Nanofibers containing activated carbon using poly(ethylene--vinyl alcohol) (EVOH) were prepared to remove indoxyl sulfate (IS) from the blood. IS is a urinary toxin that is highly toxic and triggers the progression of chronic kidney disease (CKD). Here, nanofibers containing activated carbon (AST-120), which has been used practically as an adsorbent for indole (a precursor of IS), were fabricated electrospinning for the adsorption and removal of IS from the blood. EVOH containing different ethylene ratios was used as the nanofiber material; moreover, the effect of the ethylene ratio on various properties of the nanofibers, such as surface wettability and the IS adsorption rate, was investigated. As a result, EVOH/AST-120 nanofibers comprising EVOH with a low ethylene ratio exhibited faster IS adsorption behavior. This adsorption behavior agreed well with the pseudo-second-order model, suggesting that the diffusion of IS into the nanofibers is the rate-limiting step of the process of adsorption. Furthermore, the nanofibers successfully reduced the IS concentration in the blood under circulating conditions. Therefore, these EVOH/AST-120 nanofibers are expected to greatly improve the prognosis of patients with CKD when used in combination with the current hemodialysis therapy as an IS-adsorbing filter.
制备了含有使用聚乙烯 - 乙烯醇（EVOH）的活性炭的纳米纤维，用于从血液中去除硫酸吲哚酚（IS）。IS是一种尿液毒素，具有高毒性并会引发慢性肾病（CKD）的进展。在此，通过静电纺丝制备了含有实际上已用作吲哚（IS的前体）吸附剂的活性炭（AST - 120）的纳米纤维，用于从血液中吸附和去除IS。使用含有不同乙烯比例的EVOH作为纳米纤维材料；此外，研究了乙烯比例对纳米纤维各种性能（如表面润湿性和IS吸附率）的影响。结果，由低乙烯比例的EVOH组成的EVOH/AST - 120纳米纤维表现出更快的IS吸附行为。这种吸附行为与伪二级模型吻合良好，表明IS向纳米纤维中的扩散是吸附过程的限速步骤。此外，纳米纤维在循环条件下成功降低了血液中的IS浓度。因此，这些EVOH/AST - 120纳米纤维有望在与当前血液透析疗法联合用作IS吸附过滤器时，极大地改善CKD患者的预后。
