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Standardization is needed in reporting risk and outcomes of machine perfusion in liver transplantation.肝移植中机器灌注的风险和结果报告需要标准化。
Hepatobiliary Surg Nutr. 2024 Aug 1;13(4):709-714. doi: 10.21037/hbsn-24-301. Epub 2024 Jul 18.
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Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial).采用充氧低温、复温及常温和机器灌注联合方案复苏和评估供肝活力后移植高危供肝:一项前瞻性、单臂研究的研究方案(DHOPE-COR-NMP 试验)。
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Does machine perfusion improve immediate and short-term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta-analysis and expert panel recommendations.机器灌注能否通过增强肝移植后移植物功能和受者恢复来改善近期和短期结局?一项文献系统综述、荟萃分析及专家小组建议。
Clin Transplant. 2022 Oct;36(10):e14638. doi: 10.1111/ctr.14638.
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J Surg Res. 2019 Mar;235:383-394. doi: 10.1016/j.jss.2018.09.066. Epub 2018 Nov 14.
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The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver.常温机械灌注对供肝免疫谱的影响。
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Comprehensive Approach to Assessment of Liver Viability During Normothermic Machine Perfusion.常温机器灌注期间肝脏活力评估的综合方法
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Hyperspectral Imaging as a Tool for Viability Assessment During Normothermic Machine Perfusion of Human Livers: A Proof of Concept Pilot Study.高光谱成像是一种在常温机器灌注过程中评估人类肝脏活力的工具:一项概念验证性初步研究。
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Customized normothermic machine perfusion decreases ischemia-reperfusion injury compared with static cold storage in a porcine model of liver transplantation.在猪肝移植模型中,与静态冷藏相比,定制的常温机器灌注可减少缺血再灌注损伤。
Artif Organs. 2023 Jan;47(1):148-159. doi: 10.1111/aor.14390. Epub 2022 Sep 3.

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Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Transplantation of Extended Criteria Liver Grafts: A Systematic Review and Meta-Analysis.边缘供肝移植中低温氧合灌注与静态冷藏的比较:一项系统评价和荟萃分析
Clin Transplant. 2025 Sep;39(9):e70291. doi: 10.1111/ctr.70291.
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Response to Comment on: "Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis".对关于《回基地常温机器灌注对并发症和成本的影响:一项多中心、真实世界风险匹配分析》评论的回应
Ann Surg Open. 2024 Nov 13;5(4):e525. doi: 10.1097/AS9.0000000000000525. eCollection 2024 Dec.
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Machine Perfusion as a Strategy to Decrease Ischemia-Reperfusion Injury and Lower Cancer Recurrence Following Liver Transplantation.机器灌注作为一种减少肝移植后缺血再灌注损伤及降低癌症复发的策略。
Cancers (Basel). 2024 Nov 26;16(23):3959. doi: 10.3390/cancers16233959.

本文引用的文献

1
Real-time assessment of kidney allografts during HOPE using flavin mononucleotide (FMN) - a preclinical study.使用黄素单核苷酸(FMN)对希望(HOPE)期间的同种异体肾移植进行实时评估——一项临床前研究。
Front Transplant. 2023 Feb 28;2:1132673. doi: 10.3389/frtra.2023.1132673. eCollection 2023.
2
Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis.回输常温机器灌注对并发症和成本的影响:一项多中心、真实世界风险匹配分析。
Ann Surg. 2024 Aug 1;280(2):300-310. doi: 10.1097/SLA.0000000000006291. Epub 2024 Apr 1.
3
Bile Chemistry During Ex Situ Normothermic Liver Perfusion Does Not Always Predict Cholangiopathy.在体外常温肝脏灌注过程中胆汁化学性质并不总是预测胆管病。
Transplantation. 2024 Jun 1;108(6):1383-1393. doi: 10.1097/TP.0000000000004944. Epub 2024 Feb 27.
4
Improved outcomes after hypothermic oxygenated machine perfusion in liver transplantation-Long-term follow-up of a multicenter randomized controlled trial.肝移植中低温氧合机器灌注后改善的预后——一项多中心随机对照试验的长期随访
Hepatol Commun. 2024 Feb 3;8(2). doi: 10.1097/HC9.0000000000000376. eCollection 2024 Feb 1.
5
Prolonged hypothermic machine perfusion enables daytime liver transplantation - an IDEAL stage 2 prospective clinical trial.延长低温机器灌注可实现日间肝移植——一项IDEAL 2期前瞻性临床试验
EClinicalMedicine. 2024 Jan 5;68:102411. doi: 10.1016/j.eclinm.2023.102411. eCollection 2024 Feb.
6
Discarded livers tested by normothermic machine perfusion in the VITTAL trial: Secondary end points and 5-year outcomes.在VITTAL试验中通过常温机器灌注测试的废弃肝脏:次要终点和5年结局
Liver Transpl. 2024 Jan 1;30(1):30-45. doi: 10.1097/LVT.0000000000000270. Epub 2023 Dec 15.
7
Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial.便携式低温氧合机器灌注在肝移植中器官保存的应用:一项随机、开放标签、临床试验。
Hepatology. 2024 May 1;79(5):1033-1047. doi: 10.1097/HEP.0000000000000715. Epub 2023 Dec 13.
8
Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers.胆汁蛋白质组揭示了人类供体肝脏在常温保存过程中的胆管再生。
Nat Commun. 2023 Nov 30;14(1):7880. doi: 10.1038/s41467-023-43368-y.
9
Screening for mitochondrial function before use-routine liver assessment during hypothermic oxygenated perfusion impacts liver utilization.在低温氧合灌注期间进行常规肝脏评估之前筛选线粒体功能会影响肝脏的利用。
EBioMedicine. 2023 Dec;98:104857. doi: 10.1016/j.ebiom.2023.104857. Epub 2023 Oct 31.
10
Impact of Portable Normothermic Machine Perfusion for Liver Transplantation From Adult Deceased Donors.成人尸体供肝移植中使用便携式常温机器灌流的影响。
Ann Surg. 2023 Nov 1;278(5):e922-e929. doi: 10.1097/SLA.0000000000006032. Epub 2023 Aug 15.

Standardization is needed in reporting risk and outcomes of machine perfusion in liver transplantation.

作者信息

Wehrle Chase J, Miller Charles, Hashimoto Koji, Schlegel Andrea

机构信息

Transplantation Center, Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.

Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Hepatobiliary Surg Nutr. 2024 Aug 1;13(4):709-714. doi: 10.21037/hbsn-24-301. Epub 2024 Jul 18.

DOI:10.21037/hbsn-24-301
PMID:39175732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336534/
Abstract
摘要