澳大利亚和非洲多种啮齿动物物种中与GALV-KoRV相关的逆转录病毒。
GALV-KoRV-related retroviruses in diverse Australian and African rodent species.
作者信息
Hayward Joshua A, Tian Shuoshuo, Tachedjian Gilda
机构信息
Life Sciences Discipline, Burnet Institute, 85 Commercial Rd, Melbourne, VIC 3004, Australia.
Department of Microbiology, Monash University, Wellington Rd, Clayton, VIC 3168, Australia.
出版信息
Virus Evol. 2024 Jul 31;10(1):veae061. doi: 10.1093/ve/veae061. eCollection 2024.
The enigmatic origins and transmission events of the gibbon ape leukemia virus (GALV) and its close relative the koala retrovirus (KoRV) have been a source of enduring debate. Bats and rodents are each proposed as major reservoirs of interspecies transmission, with ongoing efforts to identify additional animal hosts of GALV-KoRV-related retroviruses. In this study, we identified nine rodent species as novel hosts of GALV-KoRV-related retroviruses. Included among these hosts are two African rodents, revealing the first appearance of this clade beyond the Australian and Southeast Asian region. One of these African rodents, , carries an endogenous GALV-KoRV-related retrovirus that is fully intact and potentially still infectious. Our findings support the hypothesis that rodents are the major carriers of GALV-KoRV-related retroviruses.
长臂猿白血病病毒（GALV）及其近亲考拉逆转录病毒（KoRV）神秘的起源和传播事件一直是持久争论的源头。蝙蝠和啮齿动物都被认为是种间传播的主要宿主，人们一直在努力寻找与GALV-KoRV相关逆转录病毒的其他动物宿主。在这项研究中，我们鉴定出9种啮齿动物为与GALV-KoRV相关逆转录病毒的新宿主。这些宿主包括两种非洲啮齿动物，这揭示了该病毒分支在澳大利亚和东南亚地区以外的首次出现。其中一种非洲啮齿动物携带一种与GALV-KoRV相关的内源性逆转录病毒，该病毒完全完整且可能仍具有传染性。我们的研究结果支持了啮齿动物是与GALV-KoRV相关逆转录病毒主要携带者的假说。
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