Zakerihamidi Maryam, Hassan Boskabadi, Samin Amirkhani
Department of Midwifery, School of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon 46617-34666, Iran.
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 91778-96149, Iran.
Asian Biomed (Res Rev News). 2024 Jun 28;18(3):116-124. doi: 10.2478/abm-2024-0017. eCollection 2024 Jun.
The antioxidant system in a preterm neonate is premature. The imbalance between the prooxidant and antioxidant systems can make these neonates prone to oxidative stress. Birth asphyxia is one of the factors that can disturb this balance.
We studied the prooxidant-antioxidant balance (PAB) in the diagnosis and developmental prognosis of preterm neonates with asphyxia.
This cohort study has been conducted between 2016 and 2022 with 2 years follow-up on 183 premature neonates admitted to Ghaem Hospital Mashhad, by using a convenience sampling method. The data-collection tool and the researcher-made checklist included the mothers' and the neonate's information, and the third segment included laboratory information. PAB was studied by using standard solutions and the Enzyme immunoassays (ELISA) method. After discharging the newborns from the hospital, they were under follow-up at 6 months, 12 months, 18 months, and 24 months, by using the Denver II test. PAB was compared among newborns with asphyxia, those without asphyxia, and also newborns with normal and abnormal outcomes in both groups.
The mean ± standard deviation of the PAB factor reported is as follows: in newborns without asphyxia (21.00 ± 18.14 HK), those with asphyxia (31.00 ± 45.42 HK), in newborns with asphyxia having abnormal outcomes (40.00 ± 60.84 HK), and those having normal outcomes (21.00 ± 18.67 HK) ( ≤ 0.05). PAB results >25 HK have been used for the diagnosis of asphyxia prognosis in newborns, with 83.3% sensitivity and 81% specificity.
The PAB index showed a significant increase after asphyxia. It can be used as a diagnostic marker for the prognosis of premature newborns with asphyxia. Thus, diagnosis and prognosis of asphyxia in premature newborns can be predicted by using the PAB index.
早产儿的抗氧化系统尚未发育成熟。促氧化剂和抗氧化剂系统之间的失衡会使这些新生儿易于遭受氧化应激。出生窒息是扰乱这种平衡的因素之一。
我们研究了促氧化剂-抗氧化剂平衡（PAB）在窒息早产儿诊断和发育预后中的作用。
本队列研究于2016年至2022年进行，采用便利抽样法，对183例入住马什哈德加姆医院的早产儿进行了为期2年的随访。数据收集工具和研究者编制的检查表包括母亲和新生儿的信息，第三部分包括实验室信息。采用标准溶液和酶联免疫吸附测定（ELISA）法研究PAB。新生儿出院后，采用丹佛发育筛查测验第二版在6个月、12个月、18个月和24个月时进行随访。比较窒息新生儿、非窒息新生儿以及两组中结局正常和异常的新生儿的PAB。
报告的PAB因子的均值±标准差如下：非窒息新生儿为（21.00±18.14 HK），窒息新生儿为（31.00±45.42 HK），窒息且结局异常的新生儿为（40.00±60.84 HK），结局正常的新生儿为（21.00±18.67 HK）（P≤0.05）。PAB结果>25 HK已被用于诊断新生儿窒息预后，敏感性为83.3%，特异性为81%。
窒息后PAB指数显著升高。它可作为窒息早产儿预后的诊断标志物。因此，使用PAB指数可以预测早产新生儿窒息的诊断和预后。
