Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Eye Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran.
Eye (Lond). 2022 Jan;36(1):148-152. doi: 10.1038/s41433-021-01465-6. Epub 2021 Mar 1.
Retinopathy of prematurity (RoP) is a vasoproliferative disorder caused by the abnormal development of retinal vessels in premature neonates. It is one of the major causes of childhood blindness, which is increasing with the increasing survival rate of low birth weight and premature neonates. This study has aimed to evaluate the role of oxidative stress and peroxidant antioxidant balance (PAB) in the pathogenesis and prediction of RoP.
A total of 154 neonates weighing <1500 g admitted at the NICU of Ghaem Hospital, Mashhad, Iran, were enrolled in this cross-sectional study between 2018 and 2020. Blood samples were collected on the first day of birth to assess the peroxidant and antioxidant balance. The demographic, prenatal, and clinical course and postnatal problems were also recorded. The neonates were examined for RoP and divided into control (healthy) and affected (ROP) groups.
There were significant differences between the two groups in gestational age, duration of oxygen therapy, and first and fifth minute Apgar score (P < 0.005). The mean PAB in infants without and with ROP was 19.79 HK (Hamidi-Koliakos) and 38.45 HK, respectively (P < 0.0001). Also, the mean PAB in neonates with ROP grade 1 and 2 was 36.69 HK and 45.53 HK, respectively (P = 0.002).
According to our findings, the PAB level can be helpful in predicting ROP incidence. With increasing PAB, the possibility of ROP severity will increase.
早产儿视网膜病变（ROP）是一种血管增生性疾病，由早产儿视网膜血管的异常发育引起。它是儿童失明的主要原因之一，随着低出生体重和早产儿存活率的提高，这种疾病的发病率也在不断增加。本研究旨在评估氧化应激和过氧化物-抗氧化平衡（PAB）在 ROP 发病机制和预测中的作用。
本横断面研究于 2018 年至 2020 年在伊朗马什哈德 Ghaem 医院的 NICU 招募了 154 名体重<1500 克的新生儿。在出生的第一天采集血液样本以评估过氧化物和抗氧化平衡。还记录了人口统计学、产前、临床过程和产后问题。对新生儿进行 ROP 检查，并将其分为对照组（健康）和观察组（ROP）。
两组在胎龄、氧疗时间以及第 1 分钟和第 5 分钟 Apgar 评分方面存在显著差异（P<0.005）。无 ROP 和有 ROP 的婴儿的平均 PAB 分别为 19.79 HK（Hamidi-Koliakos）和 38.45 HK（P<0.0001）。此外，ROP 1 级和 2 级婴儿的平均 PAB 分别为 36.69 HK 和 45.53 HK（P=0.002）。
根据我们的发现，PAB 水平有助于预测 ROP 发生率。随着 PAB 的增加，ROP 严重程度的可能性将会增加。
