Sako F, Kobayashi N, Taniguchi N, Takakuwa E
J Toxicol Sci. 1978 May;3(2):127-36. doi: 10.2131/jts.3.127.
The toxicity of 14 commercial natural dyes which are widely used as food additives in Japan was studied on Paramecium caudatum. Laccaic acid and capsanthin were found to be very toxic to Paramecium caudatum. Some of the commercially available carminic acid and crocin were also toxic. The inhibitory effect of natural food dyes on leucine aminopeptidase, acid phosphatase and esterase in vitro was proportional to the toxic effect of the dyes on the survival time of Paramecium caudatum. Analyses of the commercial natural food dyes by high performance liquid chromatography failed to identify the toxic components.
在尾草履虫上研究了14种在日本被广泛用作食品添加剂的市售天然染料的毒性。发现紫胶酸和辣椒红素对尾草履虫毒性很大。一些市售的胭脂红酸和藏红花素也具有毒性。天然食用染料对亮氨酸氨肽酶、酸性磷酸酶和酯酶的体外抑制作用与染料对尾草履虫存活时间的毒性作用成正比。用高效液相色谱法对市售天然食用染料进行分析未能鉴定出有毒成分。
